Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, India.
Curr Pharm Des. 2020;26(41):5353-5361. doi: 10.2174/1381612826666200707131006.
The progressive treatment of cancer using disulfide bond-based therapeutics offers improvement in therapeutic potency of active, reduction in adverse events, prolongation of drug release pattern and on-site action by interacting with neoplastic cell microenvironment.
The objective of this article is to highlight the research carried out on disulfide bond-based drug delivery systems as a potential candidate for cancer treatment.
The article provides an overview of the importance of disulfide bonds in cancer treatment in terms of their properties, mechanism of formation/fragmentation and applications. Properties of disulfide bonds, such as pKa, entropy, and dihedral angle contribute to the structural stability of the bonds in a nanotherapeutic system, while their formation and fragmentation are attributed to the presence of a high concentration of GSH in cancer cells. The article further focuses on various drug delivery systems like dendrimers, liposomes, micelles, etc. involving disulfide cross-linked polymers for the preparation of redox-responsive drug delivery systems.
The use of nanotechnology with disulfide bond creates an anticancer drug delivery system with higher target specificity, improved bioavailability, and good therapeutic efficacy.
In the near future, the combination of DSB with active, cellular material, stem cell and biological fluid will be considered as a new thrust area for research in healthcare.
利用基于二硫键的治疗剂对癌症进行渐进式治疗，可以提高活性治疗效果、降低不良反应、延长药物释放模式，并通过与肿瘤细胞微环境相互作用实现现场作用。
本文的目的是强调基于二硫键的药物传递系统作为癌症治疗的潜在候选物的研究。
本文概述了二硫键在癌症治疗中的重要性，包括其性质、形成/断裂机制和应用。二硫键的性质，如 pKa、熵和二面角，有助于纳米治疗系统中键的结构稳定性，而其形成和断裂归因于癌细胞中存在高浓度的 GSH。本文还进一步关注了各种药物传递系统，如涉及二硫键交联聚合物的树状大分子、脂质体、胶束等，用于制备氧化还原响应性药物传递系统。
使用纳米技术与二硫键相结合，创建了一种具有更高靶向特异性、改善生物利用度和良好治疗效果的抗癌药物传递系统。
在不久的将来，将 DSB 与活性物质、细胞材料、干细胞和生物流体结合起来，将被视为医疗保健研究的一个新重点领域。
