Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Cancer and Immunology Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran; Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Life Sci. 2020 Sep 15;257:118051. doi: 10.1016/j.lfs.2020.118051. Epub 2020 Jul 4.
Chemotherapy is an effective therapeutic modality which is commonly used for battling various cancers. However, several side effects induced by chemotherapeutic drugs would limit their clinical use. The present systematic review aims to evaluate the role of curcumin/curcuminoids co-administration during gastric cancer chemotherapy.
This systematic review was done according to PRISMA guidelines and a full systematic search in the electronic databases up to May 2020 using search terms in the titles and abstracts for the identification of relevant literature. 279 articles were found in electronic databases and 175 articles screened by title and abstract. Finally, 13 articles were included in this systematic review according to our inclusion and exclusion criteria.
The findings indicated that gastric cancer chemotherapy induces cytotoxicity effects in various ways including a decrease of cell viability, colony formation, metastasis, tumor growth, and weight, as well as elevation of apoptosis pathway, oxidative stress pathway compared to the control group. Co-administration of curcumin/curcuminoids with chemotherapy synergistically increased the effects of anti-cancer chemotherapy compared to the group solo treated with chemotherapeutic agents. Also, in chemoresistance gastric cancer cells, co-administration of curcumin reduced chemoresistance mainly through the reduction of NF-κB activation and elevation of apoptosis.
According to the findings, the use of curcumin/curcuminoids during gastric cancer chemotherapy has chemosensitizing effects, and also it can reduce chemoresistance in gastric cancer.
化疗是一种有效的治疗方式，常用于治疗各种癌症。然而，化疗药物引起的一些副作用会限制其临床应用。本系统评价旨在评估姜黄素/姜黄素类化合物联合用于胃癌化疗的作用。
本系统评价按照 PRISMA 指南进行，对截至 2020 年 5 月的电子数据库进行了全面的系统检索，使用标题和摘要中的检索词来确定相关文献。在电子数据库中发现了 279 篇文章，通过标题和摘要筛选出 175 篇文章。最终，根据纳入和排除标准，有 13 篇文章纳入本系统评价。
研究结果表明，胃癌化疗通过多种途径诱导细胞毒性作用，包括降低细胞活力、集落形成、转移、肿瘤生长和体重，以及增加细胞凋亡途径、氧化应激途径，与对照组相比。与单独使用化疗药物相比，姜黄素/姜黄素类化合物与化疗联合使用可协同增强抗癌化疗的效果。此外，在化疗耐药性胃癌细胞中，姜黄素通过降低 NF-κB 激活和增加细胞凋亡来减少化疗耐药性。
根据研究结果，姜黄素/姜黄素类化合物在胃癌化疗中的应用具有化疗增敏作用，还可以降低胃癌的化疗耐药性。
