Lin Zhi, Long Fei, Zhao Mingyi, Zhang Xueyan, Yang Minghua
Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Department of Gastrointestinal Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Genomics. 2020 Nov;112(6):4000-4008. doi: 10.1016/j.ygeno.2020.06.051. Epub 2020 Jul 4.
Circular RNAs (circRNAs) are a class of noncoding RNAs (ncRNAs) that lack a 5' end cap or a 3' end poly-(A) tail and form a circular structure through covalent bonds. Compared to linear RNAs, circRNAs are more conservative and stable, and their distribution is spatiotemporally regulated. circRNAs, as a new type of competitive endogenous RNA (ceRNA), are involved in many disease processes and are also related to the occurrence and development of tumors. Over the past three years, the role of circRNAs in hematological malignancies has received increasing attention. Related research has shown that circRNAs may regulate the occurrence and development of hematological malignancies and contribute to drug resistance through a variety of molecular mechanisms. Therefore, to lay the foundation and point out directions for further research on circRNAs, this article systematically reviews the research progress on circRNAs in leukemia, lymphoma, and myeloma.
环状RNA（circRNAs）是一类非编码RNA（ncRNAs），它们缺乏5'端帽或3'端多聚（A）尾，并通过共价键形成环状结构。与线性RNA相比，circRNAs更保守、更稳定，其分布受时空调节。circRNAs作为一种新型的竞争性内源RNA（ceRNA），参与许多疾病过程，也与肿瘤的发生和发展有关。在过去三年中，circRNAs在血液系统恶性肿瘤中的作用越来越受到关注。相关研究表明，circRNAs可能通过多种分子机制调节血液系统恶性肿瘤的发生和发展，并导致耐药性。因此，为了为circRNAs的进一步研究奠定基础并指明方向，本文系统综述了circRNAs在白血病、淋巴瘤和骨髓瘤中的研究进展。
