Zhang Yue, Zhang Xinyi, Xu Yumeng, Fang Shikun, Ji Ying, Lu Ling, Xu Wenrong, Qian Hui, Liang Zhao Feng
Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
Child Healthcare Department, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Front Oncol. 2022 Apr 7;12:845703. doi: 10.3389/fonc.2022.845703. eCollection 2022.
Circular RNAs (circRNAs) are non-coding single-stranded covalently closed circular RNA, mainly produced by reverse splicing of exons of precursor mRNAs (pre-mRNAs). The characteristics of high abundance, strong specificity, and good stability of circRNAs have been discovered. A large number of studies have reported its various functions and mechanisms in biological events, such as the occurrence and development of cancer. In this review, we focus on the classification, characterization, biogenesis, functions of circRNAs, and the latest advances in cancer research. The development of circRNAs as biomarkers in cancer diagnosis and treatment also provides new ideas for studying circRNAs research.
环状RNA（circRNAs）是一类非编码单链共价闭合环状RNA，主要由前体mRNA（pre-mRNAs）外显子的反向剪接产生。环状RNA具有高丰度、强特异性和良好稳定性等特点。大量研究报道了其在生物事件中的多种功能和机制，如癌症的发生发展。在本综述中，我们重点关注环状RNA的分类、特征、生物合成、功能以及癌症研究的最新进展。环状RNA作为癌症诊断和治疗生物标志物的发展也为环状RNA的研究提供了新思路。
