Du Jingyi, Jia Feiyu, Wang Lijuan
School of Clinical Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Central Laboratory, Linyi People's Hospital, Linyi, China.
Front Oncol. 2022 Jun 20;12:900374. doi: 10.3389/fonc.2022.900374. eCollection 2022.
Circular RNAs (circRNAs) are non-protein-coding RNAs that have a circular structure and do not possess a 5 cap or 3 poly-A tail. Their structure is more stable than that of linear RNAs, and they are difficult to deform hydrolysis. Advancements in measurement technology such as RNA sequencing have enabled the detection of circRNAs in various eukaryotes in both and studies. The main function of circRNAs involves sponging of microRNAs (MiRNAs) and interaction with proteins associated with physiological and pathological processes, while some circRNAs are involved in translation. circRNAs act as tumor suppressors or oncogenes during the development of many tumors and are emerging as new diagnostic and prognostic biomarkers. They also affect resistance to certain chemotherapy drugs such as imatinib. The objective of this review is to investigate the expression and clinical significance of circRNAs in hematological malignancies. We will also explore the effect of circRNAs on proliferation and apoptosis in hematological malignancy cells and their possible use as biomarkers or targets to determine prognoses. The current literature indicates that circRNAs may provide new therapeutic strategies for patients with hematologic malignancies.
环状RNA（circRNAs）是一类非蛋白质编码RNA，具有环状结构，没有5'帽或3'聚腺苷尾。它们的结构比线性RNA更稳定，难以被水解而变形。诸如RNA测序等测量技术的进步使得在基础和临床研究中都能够检测各种真核生物中的circRNAs。circRNAs的主要功能包括充当微小RNA（miRNAs）的海绵以及与生理和病理过程相关的蛋白质相互作用，而一些circRNAs还参与翻译过程。在许多肿瘤的发生发展过程中，circRNAs可作为肿瘤抑制因子或癌基因，并且正逐渐成为新的诊断和预后生物标志物。它们还会影响对某些化疗药物（如伊马替尼）的耐药性。本综述的目的是研究circRNAs在血液系统恶性肿瘤中的表达及临床意义。我们还将探讨circRNAs对血液系统恶性肿瘤细胞增殖和凋亡的影响，以及它们作为生物标志物或预后判断靶点的潜在用途。目前的文献表明，circRNAs可能为血液系统恶性肿瘤患者提供新的治疗策略。
