School of Pharmacy, Department of Pharmacognosy, Istanbul Medipol University, 34810 Istanbul, Turkey.
Faculty of Pharmacy, Department of Pharmacognosy, Cyprus International University, 99258 Nicosia, Northern Cyprus.
Molecules. 2020 Jul 3;25(13):3040. doi: 10.3390/molecules25133040.
Several simple and prenylated coumarin derivatives were isolated from the dichloromethane extract of the root of based on moderate cytotoxic activity of the extract in COLO205, KM12 and MCF7 cancer cells. While the major prenylated furanocoumarin derivatives and osthol isolated from the dichloromethane extract were responsible for the activity in the colon and breast cancer cell lines, the 4'-acylated osthol derivatives including a novel coumarino-alkaloid; neopapillarine) demonstrated selective cytotoxic activity in A498 and UO31 renal cancer cell lines.
从 的根的二氯甲烷提取物中分离出几种简单的和prenylated 香豆素衍生物，基于提取物在 COLO205、KM12 和 MCF7 癌细胞中的中等细胞毒性活性。虽然从二氯甲烷提取物中分离出的主要prenylated 呋喃香豆素衍生物和 Osthol 负责在结肠和乳腺癌细胞系中的活性，但包括新型的 coumarino-alkaloid（即 neopapillarine）在内的 4'-acylated Osthol 衍生物在 A498 和 UO31 肾癌细胞系中表现出选择性细胞毒性活性。
