State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao; Institute of Applied Chemistry, Hebei North University, Zhangjiakou.
Drug Support Center, Peoples Liberation Army General Hospital, Beijing, China.
Pharmazie. 2020 Jul 1;75(7):313-317. doi: 10.1691/ph.2020.9170.
A magnetic targeting nanoparticle based on graphene oxide-ferroferric oxide (GO-Fe₃O₄) was investigated as a potential drug delivery vehicle. The formation of GO/Fe₃O₄ hybrid material was confirmed by Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy and transmission electron microscopy. The GO/Fe₃O₄ hybrid still shows a higher saturation magnetization of 58.42 emu/g after coating with graphene oxide. Drug loading and releasing experiments demonstrate the GO-Fe₃O₄ hybrid has a good loading capacity of (6.47±0.08) mg/mg for temozolomide and a satisfactory release under slightly acidic condition. The MTT assays of glioma C6 cells exhibits the GO-Fe₃O₄ hybrid does not display toxicity with the concentration ranged from 40 to 120 μg/mL , while the complex of temozolomide loaded on GO/Fe₃O₄ has a better inhibitory effect on the proliferation of rat glioma C6 cells. All results suggest the prepared GO/Fe₃O₄ has potential applications in targeted anticancer drug delivery.
研究了基于氧化石墨烯-四氧化三铁（GO-Fe₃O₄）的磁性靶向纳米粒子作为潜在的药物输送载体。傅里叶变换红外光谱、X 射线衍射、扫描电子显微镜和透射电子显微镜证实了 GO/Fe₃O₄ 杂化材料的形成。氧化石墨烯包覆后，GO/Fe₃O₄ 杂化仍显示出 58.42 emu/g 的更高饱和磁化强度。载药和释放实验表明，GO-Fe₃O₄ 杂化对替莫唑胺具有良好的载药能力（6.47±0.08）mg/mg，在略酸性条件下具有令人满意的释放。GO/Fe₃O₄ 负载替莫唑胺的复合物对大鼠神经胶质瘤 C6 细胞的增殖具有更好的抑制作用。所有结果表明，所制备的 GO/Fe₃O₄ 在靶向抗癌药物输送中具有潜在的应用。
