印度尼西亚奥索维朗贡鞋厂工人中苯浓度、呼气冷凝物中的苯、丙二醛、谷胱甘肽与DNA变性的关系。
Relationship of Benzene Concentration, ECR Benzene, Malondialdehyde, Glutathione, and DNA Degeneration in Shoe Industrial Workers in Osowilangun, Indonesia.
作者信息
Tualeka Abdul Rohim, Guan Ng Yee, Russeng Syamsiar S, Ahsan Ahsan, Susilowati Indri H, Rahmawati Pudji, Ain Khusnul
机构信息
Department of Occupational Health and Safety, Universitas Airlangga, Surabaya, East Java, Indonesia.
Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
出版信息
Dose Response. 2020 Jun 26;18(2):1559325820921023. doi: 10.1177/1559325820921023. eCollection 2020 Apr-Jun.
In the shoes industry, benzene constitute as one of the source of chemical hazard especially used in the gluing section. This compound is metabolized by the liver, forming free radicals in the body which can ultimately reduce the concentration of glutathione and increased malondialdehyde causing DNA degeneration. The purpose of this study was to determine the relationship between benzene concentration, excess cancer risk (ECR), malondialdehyde, glutathione, and DNA degeneration among workers in shoes industry in Osowilangun, Surabaya. This is an observational study with a cross-sectional design. The number of research samples was 25 respondents. The average concentration of benzene in workers was above the threshold (10.31 ppm). There were 15 (60%) respondents with ECR >0.0001 who experienced DNA degeneration. There was no relationship between benzene concentration, malondialdehyde, glutathione, and DNA degeneration. However, there was a relationship between benzene ECR, malondialdehyde, glutathione, and DNA degeneration in the shoe industry workers in Osowilangun.
在制鞋行业中，苯是化学危害源之一，尤其在胶合环节被使用。这种化合物在肝脏中代谢，在体内形成自由基，最终会降低谷胱甘肽的浓度并增加丙二醛，导致DNA变性。本研究的目的是确定泗水奥索维朗贡制鞋行业工人中苯浓度、超额癌症风险（ECR）、丙二醛、谷胱甘肽和DNA变性之间的关系。这是一项采用横断面设计的观察性研究。研究样本数量为25名受访者。工人苯的平均浓度高于阈值（10.31 ppm）。有15名（60%）ECR>0.0001的受访者经历了DNA变性。苯浓度、丙二醛、谷胱甘肽和DNA变性之间没有关系。然而，在泗水奥索维朗贡的制鞋行业工人中，苯ECR、丙二醛、谷胱甘肽和DNA变性之间存在关系。
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