Gibbons James T D, Wilson Andrew C, Simpson Shannon J
Telethon Kids Institute, Perth, WA, Australia.
School of Physiotherapy and Exercise Science, Curtin University, Perth, WA, Australia.
Front Pediatr. 2020 Jun 19;8:318. doi: 10.3389/fped.2020.00318. eCollection 2020.
Rates of preterm birth (<37 weeks of gestation) are increasing worldwide. Improved perinatal care has markedly increased survival of very (<32 weeks gestation) and extremely (<28 weeks gestation) preterm infants, however, long term respiratory sequalae are common among survivors. Importantly, individual's lung function trajectories are determined early in life and tend to track over the life course. Preterm infants are impacted by antenatal, postnatal and early life perturbations to normal lung growth and development, potentially resulting in significant shifts from the "normal" lung function trajectory. This review summarizes what is currently known about the long-term lung function trajectories in survivors of preterm birth. Further, this review highlights how antenatal, perinatal and early life factors are likely to contribute to individual lung health trajectories across the life course.
全球范围内，早产（妊娠<37周）率正在上升。围产期护理的改善显著提高了极早产（妊娠<32周）和超早产（妊娠<28周）婴儿的存活率，然而，长期呼吸后遗症在幸存者中很常见。重要的是，个体的肺功能轨迹在生命早期就已确定，并且往往会在生命过程中持续存在。早产婴儿受到产前、产后和生命早期对正常肺生长发育的干扰，可能导致与“正常”肺功能轨迹发生显著偏差。本综述总结了目前关于早产幸存者长期肺功能轨迹的已知情况。此外，本综述强调了产前、围产期和生命早期因素如何可能在整个生命过程中影响个体的肺健康轨迹。
