Ahmed Saleh A, Hasan Md Nur, Bagchi Damayanti, Altass Hatem M, Morad Moataz, Jassas Rabab S, Hameed Ahmed M, Patwari Jayita, Alessa Hussain, Alharbi Ahmed, Pal Samir Kumar
Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, 21955 Makkah, Saudi Arabia.
Chemistry Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt.
ACS Omega. 2020 Jun 17;5(25):15666-15672. doi: 10.1021/acsomega.0c01898. eCollection 2020 Jun 30.
Chelation therapy is one of the most effective and widely accepted methods of treatment to reduce metal toxicity caused by an excess amount of essential metals. Essential minerals play an important role in maintaining healthy human physiology. However, the presence of an excess amount of such essential metals can cause cell injury, which finally leads to severe life-threatening diseases. Chelating complexes can efficiently capture the targeted metal and can easily be excreted from the body. Commonly utilized metal chelators have major side effects including long-term damage to some organs, which has pointed out the need of less harmful biocompatible chelating agents. In this work, we have investigated the iron chelating property of curcumin through various spectroscopic tools by synthesizing and characterizing the iron-curcumin (Fe-Cur) complex. We have also investigated whether the synthesized materials are able to retain their antioxidant activity after the chelation of a substantial amount of metal ion. Our study unravels the improved antioxidant activity of the synthesized chelate complex. We further demonstrate that the proposed complex generates no significant reactive oxygen species (ROS) under dark conditions, which makes it a promising candidate for chelation therapy of iron toxicity. Femtosecond-resolved fluorescence studies further provide insight into the mechanism of activity of the new complex where electron transfer from ligand to metal has been observed prominently. Thus, the Fe-Cur complex has a potential to act as a dual activity medicine for excretion of toxic metal ions via chelation and as a therapeutic agent of oxidative stress caused by the metal ion as well.
螯合疗法是治疗因必需金属过量导致的金属中毒最有效且被广泛接受的方法之一。必需矿物质在维持人体健康生理方面发挥着重要作用。然而，过量的此类必需金属的存在会导致细胞损伤，最终引发严重的危及生命的疾病。螯合复合物能够有效地捕获目标金属，并易于从体内排出。常用的金属螯合剂有包括对某些器官的长期损害在内的主要副作用，这表明需要危害较小的生物相容性螯合剂。在这项工作中，我们通过合成和表征铁 - 姜黄素（Fe - Cur）复合物，利用各种光谱工具研究了姜黄素的铁螯合特性。我们还研究了合成材料在螯合大量金属离子后是否能够保持其抗氧化活性。我们的研究揭示了合成螯合物复合物增强的抗氧化活性。我们进一步证明，所提出的复合物在黑暗条件下不会产生显著的活性氧（ROS），这使其成为铁中毒螯合疗法的有前景的候选物。飞秒分辨荧光研究进一步深入了解了新复合物的活性机制，其中显著观察到了从配体到金属的电子转移。因此，Fe - Cur复合物有潜力作为一种具有双重活性的药物，通过螯合作用排出有毒金属离子，并作为由金属离子引起的氧化应激的治疗剂。
