Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Phytother Res. 2020 Nov;34(11):2945-2952. doi: 10.1002/ptr.6721. Epub 2020 Jul 7.
Migraine is the most common type of primary headaches. Increased levels of interleukin-6 (IL-6), calcitonin-gene-related peptide (CGRP) and nitric oxide (NO) lead to inflammation and neurogenic pain. Cinnamon has anti-inflammatory and neuroprotective properties. Thus, the aim of this study was to assess the effect of cinnamon on migraine attacks and inflammatory status. Fifty patients with migraine were randomized to receive either cinnamon powder (three capsules/day each containing 600 mg of cinnamon) or three placebo capsules/day each containing 100 mg of corn starch (control group) for 2 months. Serum levels of IL-6, CGRP and NO were measured at baseline and at the end of the study. The frequency, severity and duration of pain attacks were also recorded using questionnaire. Serum concentrations of IL-6 and NO were significantly reduced in the cinnamon group compared with the control group (p < .05). However, serum levels of CGRP remained unchanged in both groups. The frequency, severity and duration of migraine attacks were significantly decreased in the cinnamon group compared with the control group. Cinnamon supplementation reduced inflammation as well as frequency, severity and duration of headache in patients with migraine. Cinnamon could be regarded as a safe supplement to relieve pain and other complications of migraine.
偏头痛是最常见的原发性头痛类型。白细胞介素 6（IL-6）、降钙素基因相关肽（CGRP）和一氧化氮（NO）水平升高会导致炎症和神经源性疼痛。肉桂具有抗炎和神经保护作用。因此，本研究旨在评估肉桂对偏头痛发作和炎症状态的影响。将 50 名偏头痛患者随机分为两组，分别服用肉桂粉（每天 3 粒，每粒含 600 毫克肉桂）或安慰剂（每天 3 粒，每粒含 100 毫克玉米淀粉），共 2 个月。在基线和研究结束时测量血清中 IL-6、CGRP 和 NO 的水平。还通过问卷调查记录疼痛发作的频率、严重程度和持续时间。与对照组相比，肉桂组血清中 IL-6 和 NO 的浓度显著降低（p <.05）。然而，两组血清 CGRP 水平均无变化。与对照组相比，肉桂组偏头痛发作的频率、严重程度和持续时间均显著降低。肉桂补充剂可减轻炎症以及偏头痛患者头痛的频率、严重程度和持续时间。肉桂可被视为一种安全的补充剂，可缓解偏头痛的疼痛和其他并发症。
