Division of Pathology, ICAR-Indian Veterinary Research Institute , Bareilly, India.
Division of Biological & Life Sciences, Indian Institute of Public Health Gandhinagar , Ganghinagar, India.
Hum Vaccin Immunother. 2020 Dec 1;16(12):2913-2920. doi: 10.1080/21645515.2020.1842034. Epub 2020 Dec 3.
Globally, researchers are undertaking significant efforts to design and develop effective vaccines, therapeutics, and antiviral drugs to curb the spread of coronavirus disease 2019 (COVID-19). Plants have been used for the production of vaccines, monoclonal antibodies, immunomodulatory proteins, drugs, and pharmaceuticals via molecular farming/transient expression system and are considered as bioreactors or factories for their bulk production. These biological products are stable, safe, effective, easily available, and affordable. Plant molecular farming could facilitate rapid production of biologics on an industrial scale, and has the potential to fulfill emergency demands, such as in the present situation of the COVID-19 pandemic. This article aims to describe the methodology and basics of plant biopharming, in addition to its prospective applications for developing effective vaccines and antibodies to counter COVID-19.
全球范围内，研究人员正在努力设计和开发有效的疫苗、疗法和抗病毒药物，以遏制 2019 年冠状病毒病（COVID-19）的传播。通过分子农业/瞬时表达系统，植物已被用于疫苗、单克隆抗体、免疫调节蛋白、药物和药物的生产，并被视为其大规模生产的生物反应器或工厂。这些生物制品稳定、安全、有效、易于获得且价格合理。植物分子农业可以促进生物制品的快速工业化生产，并有可能满足紧急需求，例如在当前 COVID-19 大流行的情况下。本文旨在描述植物生物制药的方法和基础，以及其在开发有效疫苗和抗体以对抗 COVID-19 方面的潜在应用。
