Department of Urology, Tulane University, New Orleans, LA, USA.
Department of Urology, Tulane University, New Orleans, LA, USA.
Sex Med Rev. 2021 Oct;9(4):636-640. doi: 10.1016/j.sxmr.2020.05.006. Epub 2020 Jul 5.
There is an increased prevalence of erectile dysfunction in patients with solid organ transplant (SOT) compared with the general population. Many of these patients may become refractory to medical treatment of erectile dysfunction and penile prosthesis (PP) is often recommended. Concerns regarding the safety of PP in patients with SOT are due to their immunosuppressed state.
We aim to review all current literature on the outcomes of patients with SOT who have received PP.
A PubMed search was performed to identify articles pertaining to the outcomes of PP in patients with SOT.
We identified and included 14 studies that report on outcomes of PP placement in 143 patients with SOT and 191 non-SOT controls from interval period from 1979 to 2019. Studies included retrospective cohort studies, case series, and case reports. Compared with non-SOT controls who had PP, aggregate analysis demonstrated that patients with SOT who had PP did not develop significantly increased overall complications. However, they were significantly more likely to experience future surgical complications.
Our aggregate analysis demonstrated that patients with SOT are not at a significantly increased risk of overall complications when receiving a PP. Nevertheless, there is an increased risk of experiencing PP injury during subsequent surgeries, which may be mitigated by the earlier involvement of a urologist. Given the lack of recent data, large studies are prerequisite to further evaluate the safety and overall outcome of PP surgery in patients with SOT. Dick B, Greenberg JW, Polchert M, et al. A Systematic Review of Penile Prosthesis Surgery in Organ Transplant Recipients. Sex Med Rev 2021;9:636-640.
与普通人群相比，实体器官移植（SOT）患者的勃起功能障碍患病率增加。这些患者中有许多可能对勃起功能障碍的药物治疗产生抗药性，通常建议使用阴茎假体（PP）。由于这些患者处于免疫抑制状态，因此对 SOT 患者使用 PP 的安全性存在担忧。
我们旨在回顾所有关于接受过 PP 的 SOT 患者的研究结果。
通过 PubMed 搜索，确定了与 SOT 患者 PP 结果相关的文章。
我们确定并纳入了 14 项研究，这些研究报告了 1979 年至 2019 年期间 143 例 SOT 患者和 191 例非 SOT 对照患者的 PP 放置结果。研究包括回顾性队列研究、病例系列和病例报告。与接受过 PP 的非 SOT 对照组相比，综合分析表明，接受过 PP 的 SOT 患者总体并发症发生率没有显著增加。但是，他们发生未来手术并发症的可能性显著增加。
我们的综合分析表明，接受 PP 的 SOT 患者总体并发症的风险没有显著增加。然而，他们在随后的手术中经历 PP 损伤的风险增加，这可以通过泌尿科医生的早期参与来减轻。鉴于缺乏最新数据，需要进行大型研究以进一步评估 SOT 患者接受 PP 手术的安全性和总体结果。Dick B、Greenberg JW、Polchert M 等人。器官移植受者阴茎假体手术的系统评价。性医学评论 2021；9：636-640。
