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队列研究简介:上海郊区成人队列和生物库(SSACB)研究的方案和基线调查。

Cohort profile: protocol and baseline survey for the Shanghai Suburban Adult Cohort and Biobank (SSACB) study.

机构信息

Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.

Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, China.

出版信息

BMJ Open. 2020 Jul 8;10(7):e035430. doi: 10.1136/bmjopen-2019-035430.

DOI:10.1136/bmjopen-2019-035430
PMID:32641326
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7348462/
Abstract

PURPOSE

The Shanghai Suburban Adult Cohort and Biobank (SSACB) was established to identify environmental, lifestyle and genetic risk factors for non-communicable chronic diseases (NCDs) in adults (20-74 years old) living in a suburban area of Shanghai with rapid urbanisation.

PARTICIPANTS

Two of eight suburban district were purposely selected according to participant willingness, health service facilities, population, geographic region and electronic medical record system. From these suburban districts, four communities were selected based on economic level and population size. At stage three, one-third of the committees/villages were randomly selected from each community. All residents aged 20-74 years old were invited as study participants.

FINDINGS TO DATE

The baseline data on demographics, lifestyle and physical health-related factors were collected using a face-to-face questionnaire interview. All participants completed physical examinations and had blood and urine tests. Blood and urine samples from these tests were stored in a biobank. From 6 April 2016 through 31 October 2017, we conducted face-to-face interviews and clinical examinations in 44 887 participants: 35 727 from Songjiang District and 9160 from Jiading District. The average age of participants was 56.4±11.2 years in Songjiang and 56.6±10.5 years in Jiading. The prevalence of hypertension, diabetes and dyslipidaemia was 34.0%, 8.2% and 11.1%, respectively.

FUTURE PLANS

In-person surveys will be conducted every 5 years. For annual tracking, baseline data was linked to the local health information system, which was composed of an electronic medical record system, a chronic disease management system, a cancer registry system, an infectious disease report system and a death registry system. The data of the SSACB cohort is located in the School of Public Health, Fudan University. International and domestic collaborative research projects are encouraged and inherent in the project.

摘要

目的

上海郊区成人队列与生物库(SSACB)旨在识别生活在上海郊区城市化快速发展地区的成年人(20-74 岁)中环境、生活方式和遗传因素与非传染性慢性疾病(NCD)的关系。

参与者

根据参与者的意愿、卫生服务设施、人口、地理区域和电子病历系统,从 8 个郊区中选择了 2 个。从这些郊区中,根据经济水平和人口规模选择了 4 个社区。在第三阶段,从每个社区中随机选择三分之一的委员会/村庄。所有 20-74 岁的居民都被邀请作为研究参与者。

迄今为止的发现

使用面对面问卷访谈收集了人口统计学、生活方式和与身体健康相关因素的基线数据。所有参与者都完成了体格检查和血液及尿液检查。这些测试的血液和尿液样本被储存在生物库中。从 2016 年 4 月 6 日至 2017 年 10 月 31 日,我们对来自松江和嘉定的 44887 名参与者进行了面对面访谈和临床检查:松江有 35727 名,嘉定有 9160 名。参与者的平均年龄为松江 56.4±11.2 岁,嘉定 56.6±10.5 岁。高血压、糖尿病和血脂异常的患病率分别为 34.0%、8.2%和 11.1%。

未来计划

将每 5 年进行一次现场调查。为了进行年度跟踪,基线数据与当地卫生信息系统相关联,该系统由电子病历系统、慢性病管理系统、癌症登记系统、传染病报告系统和死亡登记系统组成。SSACB 队列的数据位于复旦大学公共卫生学院。鼓励并内在地开展国际和国内合作研究项目。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53f6/7348462/04556fdfdf39/bmjopen-2019-035430f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53f6/7348462/b41c1b525432/bmjopen-2019-035430f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53f6/7348462/7acd067b6b33/bmjopen-2019-035430f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53f6/7348462/04556fdfdf39/bmjopen-2019-035430f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53f6/7348462/b41c1b525432/bmjopen-2019-035430f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53f6/7348462/7acd067b6b33/bmjopen-2019-035430f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53f6/7348462/04556fdfdf39/bmjopen-2019-035430f03.jpg

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