Arun Krishnan R, Elizabeth Thomas Rhema, Sukumaran Ajaikumar, Paul Jofy K, Vasudevan D M
R&D Reagent Department, Agappe Diagnostics Limited, Cochin, Kerala India.
Indian J Clin Biochem. 2020 Jul;35(3):285-289. doi: 10.1007/s12291-020-00906-5. Epub 2020 Jun 27.
The novel coronavirus SARS-CoV-2 is the seventh known species of coronavirus, infectious to human beings. The pandemic COVID-19 spread all over the world with an unprecedented spreading rate after its first appearance in Wuhan, China. As a novel viral disease there in no antiviral treatment or vaccine for the COVID-19. At present, the early detection and the quarantine of infected patients are the ways to stop the spreading of the disease. This review will discuss about the current invitro diagnostic methods used worldwide for the early and accurate diagnosis of COVID-19. Currently the nucleic acid based polymerase chain reaction is used as the reliable diagnostic platform and antigen/antibody detection immunoassays are playing the role of screening tests for early detection and prognosis in COVID-19 treatment.
新型冠状病毒SARS-CoV-2是已知的第七种可感染人类的冠状病毒。新型冠状病毒肺炎疫情自首次在中国武汉出现后,以前所未有的传播速度蔓延至全球。作为一种新型病毒性疾病,目前尚无针对新型冠状病毒肺炎的抗病毒治疗方法或疫苗。目前,早期检测和隔离感染患者是阻止该疾病传播的方法。本综述将讨论目前在全球范围内用于新型冠状病毒肺炎早期准确诊断的体外诊断方法。目前,基于核酸的聚合酶链反应被用作可靠的诊断平台,抗原/抗体检测免疫测定在新型冠状病毒肺炎治疗的早期检测和预后筛查测试中发挥作用。