Spitzer E, Koepke K, Kunde D, Grosse R
Central Institute of Molecular Biology, Academy of Sciences of the German Democratic Republic, Berlin-Buch.
Breast Cancer Res Treat. 1988 Sep;12(1):45-9. doi: 10.1007/BF01805739.
Number of mitoses and EGF binding were determined in parallel in biopsies of 27 lymph-node positive and of 23 lymph-node negative breast cancer patients. For node-positive patients the parameters for cell growth and EGF binding were quantitatively correlated by the equation y = P3 + P1(1- exp(- P2x]. For node-negative cases neither the non-linear model nor the linear approximation described the data unambiguously. The results strongly suggest that in node-positive patients, growth of breast cancer is related to an EGF-dependent acceleration of cell division.
在27例淋巴结阳性和23例淋巴结阴性乳腺癌患者的活检样本中，同时测定了有丝分裂数和表皮生长因子（EGF）结合情况。对于淋巴结阳性患者，细胞生长参数和EGF结合情况通过方程y = P3 + P1(1 - exp(- P2x)进行定量关联。对于淋巴结阴性患者，无论是非线性模型还是线性近似都无法明确描述这些数据。结果强烈表明，在淋巴结阳性患者中，乳腺癌的生长与EGF依赖的细胞分裂加速有关。
