一种新的 EN1839 方法 T 混合物制备方法，用于为麻醉气体监测器制备校准气体混合物。

A new implementation of EN1839 method T mixture preparation to prepare calibration gas mixtures for anesthetic gas monitors.

机构信息

Fire and Explosion Protection Laboratory, National Institute of Standards, El-sadat street, El-Haram, P.O. Box 136, El-Giza, 12211, Egypt.

Saudi Standards, Metrology and Quality Organization, P.O. Box 3437, Riyadh, 11471, Kingdom of Saudi Arabia.

出版信息

J Clin Monit Comput. 2021 Oct;35(5):1069-1076. doi: 10.1007/s10877-020-00554-3. Epub 2020 Jul 8.

DOI:10.1007/s10877-020-00554-3

PMID:32643129

Abstract

In this study different mixtures from anesthetic liquids vapours in air and O-sevoflurane/air, sevoflurane/O and isoflurane/O-were prepared according to EN1839 method T. The gases mixtures were used to calibrate anesthetic gas monitors. The targeted concentrations (TCs) from sevoflurane and isoflurane in air and O were 0 vol%, 0.15 vol%, 0.7 vol%, 1 vol%, 1.5 vol%, 2.5 vol%, 5 vol%, 6 vol% and 8 vol%. The values of liquids, air and O flow rates which are corresponding theoretically to the TCs were calculated. The results showed that the measured concentrations by anesthetic gas monitor are in good agreement with TCs. Full validation was performed to assure the suitability of the method for preparing gas mixtures to calibrate anesthetic gas monitors. Linearity, limit of detection (LOD), limit of quantification (LOQ), precision, method robustness and uncertainty of measurement results were evaluated in the validation study. The results indicated that the method is valid for the purpose of analysis.

摘要

在这项研究中，根据 EN1839 方法 T，制备了来自麻醉液体蒸气和 O-七氟醚/空气、七氟醚/O 和异氟醚/O 混合物的不同空气混合物。使用这些混合气体来校准麻醉气体监测器。目标浓度（TCs）在空气中和 O 中的七氟醚和异氟醚分别为 0 体积%、0.15 体积%、0.7 体积%、1 体积%、1.5 体积%、2.5 体积%、5 体积%、6 体积%和 8 体积%。计算了理论上与 TCs 相对应的液体、空气和 O 流量值。结果表明，麻醉气体监测器测量的浓度与 TCs 吻合良好。进行了全面验证，以确保该方法适合制备用于校准麻醉气体监测器的混合气体。在验证研究中评估了线性、检测限（LOD）、定量限（LOQ）、精密度、方法稳健性和测量结果的不确定度。结果表明，该方法适用于分析目的。