脑胶质瘤中人类巨细胞病毒和人类乳头瘤病毒的研究。

Investigation of Human Cytomegalovirus and Human Papillomavirus in Glioma.

机构信息

Pathology Department, Farhet Hached University Hospital, Sousse, Tunisia.

Research Unit UR14ES17, Medicine Faculty, Sousse University, Sousse, Tunisia.

出版信息

Cancer Invest. 2020 Aug;38(7):394-405. doi: 10.1080/07357907.2020.1793352. Epub 2020 Jul 27.

DOI:10.1080/07357907.2020.1793352

PMID:32643440

Abstract

The study investigated the human cytomegalovirus (HCMV) and human papillomavirus (HPV) in gliomas. A retrospective study was conducted on 112 samples. HCMV was investigated by PCR, hybridization (ISH) and immunohistochemistry. HPV was tested by PCR and DNA ISH. HCMV was identified in 60 gliomas, including 55 GBM. However, RNA ISH and immunohistochemistry failed to detect HCMV positivity. HPV was identified in 44 GBM. No significant relationship was identified between HCMV and HPV and tumour characteristics ( > 0.05). Our findings support the HCMV and HPV presence in gliomas. Further assays are required to more explore the potential efficient antiviral management.

摘要

本研究调查了神经胶质瘤中的人类巨细胞病毒（HCMV）和人乳头瘤病毒（HPV）。对 112 个样本进行了回顾性研究。通过 PCR、杂交（ISH）和免疫组织化学检测 HCMV。通过 PCR 和 DNA ISH 检测 HPV。在 60 例神经胶质瘤中发现了 HCMV，其中包括 55 例 GBM。然而，RNA ISH 和免疫组织化学未能检测到 HCMV 阳性。在 44 例 GBM 中鉴定出 HPV。HCMV 和 HPV 与肿瘤特征之间未发现显著关系（>0.05）。我们的研究结果支持 HCMV 和 HPV 存在于神经胶质瘤中。需要进一步的检测来更深入地探索潜在的有效的抗病毒治疗。