关于外泌体在 COVID-19 再感染/再激活机会中的潜在作用。
On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity.
机构信息
Department of Endemic Medicine and Hepatogastroenterology, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt.
Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
出版信息
J Biomol Struct Dyn. 2021 Sep;39(15):5831-5842. doi: 10.1080/07391102.2020.1790426. Epub 2020 Jul 9.
We propose here that one of the potential mechanisms for the relapse of the COVID-19 infection could be a cellular transport pathway associated with the release of the SARS-CoV-2-loaded exosomes and other extracellular vesicles. It is possible that this "Trojan horse" strategy represents possible explanation for the re-appearance of the viral RNA in the recovered COVID-19 patients 7-14 day post discharge, suggesting that viral material was hidden within such exosomes or extracellular vesicles during this "silence" time period and then started to re-spread again.Communicated by Ramaswamy H. Sarma.
我们在这里提出，COVID-19 感染复发的潜在机制之一可能是与 SARS-CoV-2 负载的外泌体和其他细胞外囊泡释放相关的细胞转运途径。这种“特洛伊木马”策略可能为 COVID-19 患者出院后 7-14 天病毒 RNA 再次出现提供了可能的解释，表明在这段“静默”期内，病毒物质隐藏在外泌体或细胞外囊泡中，然后开始再次传播。通讯作者：Ramaswamy H. Sarma。
Zotero 插件