Gupta S, Pahwa R, Siegal F P, Good R A
Clin Exp Immunol. 1977 May;28(2):347-51.
Mononuclear cells from twenty human tonsils and peripheral blood lymphocytes were examined for T, B and 'third population cells'. Compared with peripheral blood lymphocytes, tonsils were found to have a higher proportion of B lymphocytes with surface IgM, IgD and IgA. Mouse erythrocyte rosette-forming cells were also present in increased proportions. However, 'third population cells' were found in very low proportions. Phagocytic cells as determined by latex ingestion and peroxidase staining were also present in low proportions. The lack of 'third population cells' in human tonsils may establish this organ as one of particular interest in the study of lymphocyte subpopulations because T and B lymphocytes can be purified without contaminating 'third population cells'. The role of the third population of lymphocytes in antibody-dependent cytotoxicity and spontaneous cytotoxicity may be supported by the absence of these functions along with absence of the 'third population' cells from tonsilar lymphoid cells.
对来自20个人类扁桃体的单核细胞和外周血淋巴细胞进行了T、B和“第三群细胞”检测。与外周血淋巴细胞相比，发现扁桃体中具有表面IgM、IgD和IgA的B淋巴细胞比例更高。小鼠红细胞花环形成细胞的比例也有所增加。然而，“第三群细胞”的比例非常低。通过乳胶吞噬和过氧化物酶染色确定的吞噬细胞比例也很低。人类扁桃体中缺乏“第三群细胞”，这可能使该器官成为淋巴细胞亚群研究中特别感兴趣的对象之一，因为T和B淋巴细胞可以被纯化而不被“第三群细胞”污染。扁桃体淋巴样细胞中缺乏这些功能以及“第三群”细胞，可能支持了淋巴细胞第三群在抗体依赖性细胞毒性和自发细胞毒性中的作用。
