Isenberg D A, Williams W, Le Page S, Swana G, Feldman R, Addison I, Bakimer R, Shoenfeld Y
Immunology Department, St. Thomas' Hospital, London.
Br J Rheumatol. 1988 Dec;27(6):431-5. doi: 10.1093/rheumatology/27.6.431.
In order to determine whether environmental influence per se might influence autoantibody production, sera from the spouses of 20 SLE patients were examined. No antibodies to cardiolipin, poly (ADP-ribose), or ENA were detected and none had detectable rheumatoid factor. One weakly positive ANA reaction was noted, one had anti-DNA antibodies (by RIA and ELISA) and in two sera the common DNA antibody idiotype 16/6 was found. The idiotype was not, however, present on either anti-DNA or anti-K30 antibodies. Although long-term analyses are required, it is evident that sharing the same environment with patients who commonly express a wide range of autoantibodies and common idiotypes rarely leads to their expression in non-autoimmune subjects.
为了确定环境影响本身是否可能影响自身抗体的产生，我们检测了20例系统性红斑狼疮（SLE）患者配偶的血清。未检测到抗心磷脂、聚（ADP - 核糖）或可提取核抗原（ENA）的抗体，且均未检测到类风湿因子。观察到1例弱阳性抗核抗体（ANA）反应，1例有抗DNA抗体（通过放射免疫分析和酶联免疫吸附测定），并且在两份血清中发现了常见的DNA抗体独特型16/6。然而，该独特型在抗DNA或抗K30抗体上均未出现。尽管需要进行长期分析，但显然与通常表达多种自身抗体和常见独特型的患者共享相同环境很少会导致这些抗体在非自身免疫性个体中表达。
