系统性红斑狼疮及其他自身免疫性疾病中聚（二磷酸腺苷 - 核糖）自身抗体的研究
Studies on autoantibodies to poly (adenosine diphosphate-ribose) in SLE and other autoimmune diseases.
作者信息
Morrow W J, Isenberg D A, Parry H F, Shen L, Okolie E E, Farzaneh F, Shall S, Snaith M L
出版信息
Ann Rheum Dis. 1982 Aug;41(4):396-402. doi: 10.1136/ard.41.4.396.
Abstract
Sera from 41 patients with systemic lupus erythematosus (SLE), 87 controls with various diseases, and 30 normal subjects were examined for poly (adenosine diphosphate-ribose) and ds DNA binding. Elevated levels of poly (ADP-ribose) binding were found in 73% of the SLE patients compared with 58% who had raised ds DNA binding. In a further study of 160 sera from 27 patients with SLE, levels of antipoly (ADP-ribose) antibodies were shown to correlate with clinical activity better than either anti-ds DNA or ss DNA antibodies.
摘要
对41例系统性红斑狼疮（SLE）患者、87例患有各种疾病的对照者以及30名正常受试者的血清进行了多聚（二磷酸腺苷核糖）和双链DNA结合检测。与双链DNA结合升高的58%的SLE患者相比，73%的SLE患者多聚（ADP - 核糖）结合水平升高。在对27例SLE患者的160份血清进行的进一步研究中，抗多聚（ADP - 核糖）抗体水平与临床活动的相关性优于抗双链DNA或抗单链DNA抗体。
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