Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.
Harvard Medical School, Boston, Massachusetts, USA.
J Pediatric Infect Dis Soc. 2020 Nov 10;9(5):630-635. doi: 10.1093/jpids/piaa084.
Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in pediatric patients are mild or asymptomatic. However, infants have emerged at higher risk of hospitalization and severe outcomes in pediatric coronavirus disease 2019 (COVID-19). We report a case series of 4 full-term neonates hospitalized with fever and found to have SARS-CoV-2 infection with a spectrum of illness severities. Two neonates required admission to the intensive care unit for respiratory insufficiency and end organ involvement. Half of the patients were found to have a coinfection. One neonate received antiviral therapy with remdesivir and is, to our knowledge, the youngest patient to receive this drug for COVID-19. All neonates had favorable outcomes.
大多数儿童 SARS-CoV-2（严重急性呼吸综合征冠状病毒 2）感染为轻症或无症状。然而，在儿童 2019 年冠状病毒病（COVID-19）中，婴儿有更高的住院和重症风险。我们报告了 4 例足月新生儿发热住院的病例系列，这些患儿均确诊 SARS-CoV-2 感染，疾病严重程度不一。2 例新生儿因呼吸功能不全和终末器官受累而需要入住重症监护病房。半数患儿合并感染。1 例患儿接受了瑞德西韦的抗病毒治疗，据我们所知，这是接受该药物治疗 COVID-19 的年龄最小的患者。所有新生儿的结局均良好。
