Office of Academic Affairs, Konkuk University, Chungju-si 27478, Korea.
Department of Sport, Health and Rehabilitation, College of Physical Education, Kookmin University, Seoul 02707, Korea.
Int J Environ Res Public Health. 2020 Jul 7;17(13):4900. doi: 10.3390/ijerph17134900.
Myostatin A55T genotype is one of the candidates showing inter-individual variation in skeletal muscle phenotypes. The aim of this study was to investigate the effect of the myostatin A55T genotype on markers of muscle damage after eccentric exercise. Forty-eight young, healthy male college students (age = 24.8 ± 2.2 years, height = 176.7 ± 5.3 cm, weight = 73.7 ± 8.3 kg) were enrolled in this study, and muscle damage was induced through 50 reps of maximal eccentric muscle contraction. As markers of muscle damage, maximal isometric strength (MIS), muscle soreness, creatine kinase (CK), and aspartate transaminase (AST) were measured. Myostatin A55T genotypes were classified into homozygous myostatin A55T allele (AA, n = 34, 72%), heterozygous myostatin A55T allele (AT, n = 13, 26%), and homozygous mutant carriers (TT, n = 1, 2%). After eccentric exercise, the subjects with heterozygous for AT showed markedly quicker MIS recovery compared to the AA group ( = 0.042). However, there were no significant variations in muscle soreness ( = 0.379), CK ( = 0.955), and AST ( = 0.706) among the groups. These results suggest that AT in myostatin A55T genotype may be associated with quicker strength recovery following exercise-induced muscle damage.
肌肉生长抑制素 A55T 基因型是个体间骨骼肌表型差异的候选因素之一。本研究旨在探讨肌肉生长抑制素 A55T 基因型对离心运动后肌肉损伤标志物的影响。本研究纳入了 48 名年轻健康的男性大学生（年龄=24.8±2.2 岁，身高=176.7±5.3cm，体重=73.7±8.3kg），通过 50 次最大离心肌肉收缩诱导肌肉损伤。作为肌肉损伤的标志物，测量了最大等长力量（MIS）、肌肉酸痛、肌酸激酶（CK）和天冬氨酸转氨酶（AST）。肌肉生长抑制素 A55T 基因型分为纯合肌肉生长抑制素 A55T 等位基因（AA，n=34，72%）、杂合肌肉生长抑制素 A55T 等位基因（AT，n=13，26%）和纯合突变携带者（TT，n=1，2%）。在离心运动后，AT 杂合的受试者与 AA 组相比，MIS 恢复明显更快（=0.042）。然而，肌肉酸痛（=0.379）、CK（=0.955）和 AST（=0.706）在各组之间没有显著差异。这些结果表明，肌肉生长抑制素 A55T 基因型中的 AT 可能与运动诱导的肌肉损伤后力量恢复更快有关。
