Human Nutrition, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, UK.
Institute for Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8QQ, UK.
Nutrients. 2020 Jul 7;12(7):2018. doi: 10.3390/nu12072018.
The etiopathogenesis of Inflammatory bowel disease (IBD) is a result of a complex interaction between host immune response, the gut microbiome and environmental factors, such as diet. Although scientific advances, with the use of biological medications, have revolutionized IBD treatment, the challenge for maintaining clinical remission and delaying clinical relapse is still present. As exclusive enteral nutrition has become a well-established treatment for the induction of remission in pediatric Crohn's disease, the scientific interest regarding diet in IBD is now focused on the development of follow-on dietary strategies, which aim to suppress colonic inflammation and delay a disease flare. The objective of this review is to present an extensive overview of the dietary strategies, which have been used in the literature to maintain clinical remission in both Crohn's disease and Ulcerative colitis, and the evidence surrounding the association of dietary components with clinical relapse. We also aim to provide study-related recommendations to be encompassed in future research studies aiming to investigate the role of diet during remission periods in IBD.
炎症性肠病（IBD）的病因是宿主免疫反应、肠道微生物组和环境因素（如饮食）之间复杂相互作用的结果。尽管科学的进步，包括生物药物的使用，已经彻底改变了 IBD 的治疗方法，但维持临床缓解和延迟临床复发的挑战仍然存在。由于完全肠内营养已成为诱导儿科克罗恩病缓解的一种成熟治疗方法，因此 IBD 领域的饮食科学研究现在集中在开发后续饮食策略上，这些策略旨在抑制结肠炎症并延迟疾病发作。本综述的目的是广泛介绍文献中用于维持克罗恩病和溃疡性结肠炎临床缓解的饮食策略，以及饮食成分与临床复发之间关联的证据。我们还旨在为未来旨在研究 IBD 缓解期饮食作用的研究提供相关建议。
