Yan Jiuliang, Zhou Binghai, Li Hui, Guo Lei, Ye Qinghai
Department of Liver Surgery & Transplantation, Liver Cancer Institute & Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Key Laboratory of Carcinogenesis & Cancer Invasion (Fudan University), Ministry of Education, Fudan University, Shanghai, 200032, China.
Hepat Oncol. 2020 Jun 29;7(2):HEP22. doi: 10.2217/hep-2020-0006.
Hepatocellular carcinoma (HCC) is one of the most common liver malignancies and is a leading cause of cancer-related deaths. Most HCC patients are diagnosed at an advanced stage and current treatments show poor therapeutic efficacy. It is particularly urgent to explore early diagnosis methods and effective treatments of HCC. There are a growing number of studies that show GOLM1 is one of the most promising markers for early diagnosis and prognosis of HCC. It is also involved in immune regulation, activation and degradation of intracellular signaling factors and promotion of epithelial-mesenchymal transition. GOLM1 can promote HCC progression and metastasis. The understanding of the GOLM1 regulation mechanism may provide new ideas for the diagnosis, monitoring and treatment of HCC.
肝细胞癌（HCC）是最常见的肝脏恶性肿瘤之一，也是癌症相关死亡的主要原因。大多数HCC患者在晚期被诊断出来，目前的治疗方法显示出较差的治疗效果。探索HCC的早期诊断方法和有效治疗方法尤为迫切。越来越多的研究表明，GOLM1是HCC早期诊断和预后最有希望的标志物之一。它还参与免疫调节、细胞内信号因子的激活和降解以及上皮-间质转化的促进。GOLM1可以促进HCC的进展和转移。对GOLM1调控机制的理解可能为HCC的诊断、监测和治疗提供新思路。
