Fusco Domenico, Ferrini Alessandro, Pasqualetti Giuseppe, Giannotti Chiara, Cesari Matteo, Laudisio Alice, Ballestrero Alberto, Scabini Stefano, Odetti Patrizio R, Colloca Giuseppe F, Monzani Fabio, Nencioni Alessio, Antonelli Incalzi Raffaele, Monacelli Fiammetta
Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Teaching Hospital 'Agostino Gemelli', Rome, Italy.
Geriatric Unit, Campus Bio-Medico University, Rome, Italy.
Eur J Clin Invest. 2021 Jan;51(1):e13347. doi: 10.1111/eci.13347. Epub 2020 Nov 9.
Optimizing the approach to older adults with cancer is now a priority given the increasing frequency of new cancer diagnoses that are made in the older population. The comprehensive geriatric assessment (CGA) represents the gold-standard for (1) defining prognosis and ability to withstand cancer treatments, (2) exploring the multiple aspects that define the complexity of frail older persons, and (3) designing person-tailored interventions.
In this document, based on a comprehensive revision of the literature, the Italian Society for Geriatrics and Gerontology proposes a CGA model (ONCOGER CGA) to be adopted by oncology centers for their routine approach to older patients with cancer.
A widespread use of this standardized CGA format will facilitate comparisons across institutions, promote studies based on a multidimensional patient assessment, and foster the inclusion of geriatric endpoints in oncological clinical trials. Furthermore, we predict that the use of a standardized CGA approach will increase the integration of geriatricians into oncology care teams with the final result of improving therapeutic choices and clinical outcomes.
鉴于老年人群中新发癌症诊断频率的增加，优化老年癌症患者的治疗方法现已成为一项优先任务。综合老年评估（CGA）是（1）确定预后和耐受癌症治疗能力、（2）探索界定体弱老年人复杂性的多个方面、以及（3）设计个性化干预措施的金标准。
在本文档中，基于对文献的全面修订，意大利老年医学与老年学学会提出了一种CGA模型（ONCOGER CGA），供肿瘤中心在对老年癌症患者的常规治疗中采用。
广泛使用这种标准化的CGA格式将便于跨机构比较、促进基于多维度患者评估的研究，并推动在肿瘤临床试验中纳入老年终点指标。此外，我们预计使用标准化的CGA方法将增加老年医学专家融入肿瘤护理团队，最终改善治疗选择和临床结果。
