生物材料引起的补体激活。
Complement activation produced by biomaterials.
作者信息
Chenoweth D E
机构信息
Baxter Healthcare Corporation, Round Lake, IL 60073.
出版信息
Artif Organs. 1988 Dec;12(6):508-10. doi: 10.1111/j.1525-1594.1988.tb02815.x.
Abstract
The complement-activating potential of biomaterials may be defined by appropriate application of C3a and C5a anaphylatoxin radioimmunoassays. Studies performed with hemodialysis membranes demonstrate that blood contact with these model biomaterials results in complement activation that may be ascribed to specific properties of the material surface. Further delineation of these chemical and physical properties may permit design of biocompatible materials.
摘要
生物材料的补体激活潜力可以通过适当应用C3a和C5a过敏毒素放射免疫测定来定义。对血液透析膜进行的研究表明，血液与这些模型生物材料接触会导致补体激活，这可能归因于材料表面的特定特性。进一步描述这些化学和物理特性可能有助于设计生物相容性材料。
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