银屑病及炎性脓疱性皮肤病鳞屑中过敏毒素C3a、C4a和C5a的证实
Demonstration of anaphylatoxins C3a, C4a and C5a in the scales of psoriasis and inflammatory pustular dermatoses.
作者信息
Takematsu H, Ohkohchi K, Tagami H
出版信息
Br J Dermatol. 1986 Jan;114(1):1-6. doi: 10.1111/j.1365-2133.1986.tb02773.x.
Abstract
Complement components C3a, C4a and C5a were assayed in corneal scale extracts from psoriasis and other dermatoses characterized by sterile subcorneal pustules, using radioimmunoassay. Larger amounts were detected in psoriasis and related pustular dermatoses than in extracts of non-inflammatory stratum corneum. It is concluded that complement is activated via the classical pathway and releases the neutrophil chemotactic fragment C5a.
摘要
采用放射免疫分析法，对银屑病及其他以无菌性角膜下脓疱为特征的皮肤病的角膜鳞屑提取物中的补体成分C3a、C4a和C5a进行了检测。与非炎性角质层提取物相比，在银屑病及相关脓疱性皮肤病中检测到的这些成分含量更高。得出结论，补体通过经典途径被激活并释放中性粒细胞趋化片段C5a。
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