时间连续性与衰老：记忆组织在认知衰退中的作用。
Temporal contiguity and ageing: The role of memory organization in cognitive decline.
机构信息
EPIC Center, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada.
Faculty of Psychology, Liverpool John Moores University, Liverpool, UK.
出版信息
J Neuropsychol. 2021 Apr;15 Suppl 1:53-65. doi: 10.1111/jnp.12219. Epub 2020 Jul 11.
The temporal contiguity effect is the tendency to form associations between items presented in nearby study positions. In the present study, we explored whether temporal contiguity predicted conversion to cognitively unimpaired-declining (CUD) status from a baseline of unimpaired older adults. Data from 419 participants were drawn from the Wisconsin Registry of Alzheimer's Prevention (WRAP) data set and analysed with binary logistic regressions. Temporal contiguity was calculated using the Rey Auditory Verbal Learning Test. Other predictors included age, years of education, sex, APOE-ε4 status, and other measures of memory recall. Lower temporal contiguity predicted conversion to CUD after accounting for covariates. These findings support the hypothesis that temporal organization in memory is related to cognitive decline and suggest that temporal contiguity may be used for studies of early detection.
时间连续性效应是指在附近的学习位置呈现的项目之间形成联想的趋势。在本研究中，我们探讨了时间连续性是否可以预测从认知正常但逐渐衰退（CUD）的基线状态转变为认知正常的老年人。该研究的数据来自威斯康星州阿尔茨海默病预防登记处（WRAP）数据集，通过二项逻辑回归进行分析。使用 Rey 听觉言语学习测试来计算时间连续性。其他预测因素包括年龄、受教育年限、性别、APOE-ε4 状态以及其他记忆召回措施。在考虑了协变量后，较低的时间连续性预测向 CUD 转变。这些发现支持了记忆中的时间组织与认知衰退有关的假设，并表明时间连续性可能用于早期检测研究。
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