Children's Hospital, University Hospital Cologne, Cologne, Germany.
Department of Dermatology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
J Cosmet Dermatol. 2020 Apr;19(4):827-835. doi: 10.1111/jocd.13113. Epub 2019 Aug 26.
Androgenetic alopecia (male pattern and female pattern hair loss) is characterized by thinning of the scalp hair. Intradermal injection of autologous platelet-rich plasma (PRP) might have an effect on hair regrowth.
The aim was to evaluate efficacy and safety of platelet-rich plasma compared to placebo or no treatment in people with pattern hair loss.
PATIENTS/METHODS: We searched the databases CENTRAL and MEDLINE on December 24, 2018 and included randomized controlled trials (RCTs). Primary outcomes were mean change of hair density from baseline and serious treatment-related adverse events. Secondary outcome was mean change of hair thickness from baseline. Time point of outcome assessment was 6 months after start of treatment.
We identified 13 relevant randomized controlled trials with 356 randomized (343 analyzed) people or half-head areas who received PRP in a simple parallel or half-head design. The pooled data of seven studies (171 analyzed people or half-head areas) were favorable in the PRP group on hair density. We estimated a mean difference from baseline of 30.35 associated with a wide 95% confidence interval (1.77-58.93), a considerable heterogeneity (I = 100%), and unclear risk of bias in most of the studies. Regarding hair thickness, data were also favorable in the PRP group, but these data were limited to a single study. We did not identify serious treatment-related adverse events.
The results of seven RCTs indicated that autologous platelet-rich plasma was associated with an increase of hair density when compared to placebo.
雄激素性脱发（男性型和女性型脱发）的特征是头皮毛发变薄。真皮内注射自体富血小板血浆（PRP）可能对毛发生长有影响。
本研究旨在评估 PRP 与安慰剂或不治疗相比，在脱发模式人群中的疗效和安全性。
患者/方法：我们于 2018 年 12 月 24 日在 CENTRAL 和 MEDLINE 数据库中进行了检索，并纳入了随机对照试验（RCT）。主要结局是从基线开始的毛发密度的平均变化和严重的与治疗相关的不良事件。次要结局是从基线开始的毛发厚度的平均变化。评估结局的时间点是治疗开始后 6 个月。
我们确定了 13 项相关的随机对照试验，涉及 356 名接受 PRP 治疗的（343 名进行了分析）参与者或半头面积的参与者，这些参与者接受了简单的平行或半头设计。七项研究（171 名参与者或半头面积进行了分析）的汇总数据表明，PRP 组的毛发密度更有利。我们估计从基线开始的平均差异为 30.35，置信区间（95%CI）较宽，为 1.77-58.93，存在相当大的异质性（I = 100%），并且大多数研究的偏倚风险不明确。关于毛发厚度，PRP 组的数据也有利，但这些数据仅限于一项研究。我们没有发现严重的与治疗相关的不良事件。
七项 RCT 的结果表明，与安慰剂相比，自体富血小板血浆与毛发密度的增加有关。
