Nutrition Department, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Nutr Neurosci. 2022 Mar;25(3):642-647. doi: 10.1080/1028415X.2020.1792618. Epub 2020 Jul 13.
This cross-sectional study aimed to evaluate the association of dietary fatty acids, cholesterol and omega-6/omega-3 ratio to depressive symptoms in a sample of low-risk pregnant women. Pregnant women ( = 60) within 20-40 years of age and with 22-24 gestational weeks were evaluated. Food intake was assessed by two 24-h recalls and depressive symptoms according to the Edinburgh Postnatal Depression Scale. The prevalence of depressive symptoms was 18.3%. The Prevalence Ratio (PR) adjusted by per capita income, history of depression and pregnancy intention, showed a higher prevalence of depressive symptoms among pregnant women with excessive total fatty acid intake (PR: 5.80; CI95% 1.20-27.7) and omega-6/omega-3 ratio above 10:1 (PR: 3.63; CI95% 1.20-10.94). Our results indicated a higher risk of depressive symptoms among pregnant women with total fatty acids intake and omega-6/omega-3 ratio above recommendation, but further studies are required to elucidate the mechanism of dietary fatty acids in the onset of maternal depression.
本横断面研究旨在评估饮食中的脂肪酸、胆固醇和 ω-6/ω-3 比值与低风险孕妇抑郁症状之间的关联。研究对象为年龄在 20-40 岁、妊娠 22-24 周的孕妇（n=60）。通过两次 24 小时回忆法评估食物摄入量，采用爱丁堡产后抑郁量表评估抑郁症状。抑郁症状的患病率为 18.3%。经人均收入、抑郁史和妊娠意愿调整后的患病率比（PR）显示，总脂肪酸摄入过多（PR：5.80；95%CI95% 1.20-27.7）和 ω-6/ω-3 比值高于 10:1（PR：3.63；95%CI95% 1.20-10.94）的孕妇抑郁症状患病率更高。我们的结果表明，总脂肪酸摄入和 ω-6/ω-3 比值高于推荐值的孕妇发生抑郁症状的风险更高，但需要进一步的研究来阐明膳食脂肪酸在产妇抑郁发病机制中的作用。
