Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, India.
Faculty Recharge Programme, University Grants Commission (UGC-FRP), New Delhi, India.
Am J Alzheimers Dis Other Demen. 2022 Jan-Dec;37:15333175221078418. doi: 10.1177/15333175221078418.
A significant portion of COVID-19 patients and survivors display marked clinical signs of neurocognitive impairments. SARS-CoV-2-mediated peripheral cytokine storm and its neurotropism appear to elicit the activation of glial cells in the brain proceeding to neuroinflammation. While adult neurogenesis has been identified as a key cellular basis of cognitive functions, neuroinflammation-induced aberrant neuroregenerative plasticity in the hippocampus has been implicated in progressive memory loss in ageing and brain disorders. Notably, recent histological studies of post-mortem human and experimental animal brains indicate that SARS-CoV-2 infection impairs neurogenic process in the hippocampus of the brain due to neuroinflammation. Considering the facts, this article describes the prominent neuropathogenic characteristics and neurocognitive impairments in COVID-19 and emphasizes a viewpoint that neuroinflammation-mediated deterioration of hippocampal neurogenesis could contribute to the onset and progression of dementia in COVID-19. Thus, it necessitates the unmet need for regenerative medicine for the effective management of neurocognitive deficits in COVID-19.
相当一部分 COVID-19 患者和幸存者表现出明显的神经认知障碍临床症状。SARS-CoV-2 介导的外周细胞因子风暴及其嗜神经性似乎引发了大脑中神经胶质细胞的激活，进而引发神经炎症。虽然成人神经发生已被确定为认知功能的关键细胞基础，但神经炎症诱导的海马体异常神经再生可塑性与衰老和脑部疾病中的进行性记忆丧失有关。值得注意的是，最近对死后人和实验动物大脑的组织学研究表明，SARS-CoV-2 感染会因神经炎症而损害大脑中海马体的神经发生过程。鉴于这些事实，本文描述了 COVID-19 中的突出神经发病特征和神经认知障碍，并强调了一个观点，即神经炎症介导的海马体神经发生恶化可能导致 COVID-19 中痴呆症的发生和发展。因此，迫切需要再生医学来有效管理 COVID-19 中的神经认知缺陷。
