Agyemang A O, Mensah M L K, Yamile R C, Ocloo A, Appiah A A, Mensah A Y, Thomford K P
Department of Herbal Medicine, Upper West Regional Hospital, Ghana Health Service, Wa, Ghana.
Institute of Traditional and Alternative Medicine, University of Health and Allied Sciences, Ho, Ghana.
Evid Based Complement Alternat Med. 2020 Jun 21;2020:9596182. doi: 10.1155/2020/9596182. eCollection 2020.
The incidence of liver diseases is increasing globally, and many patients in developing countries are resorting to the use of herbal products as treatment. This study was aimed at establishing the safety and effectiveness outcomes for patients with deranged liver panel treated with a Ghanaian finished polyherbal product. The product is prepared by CPMR from three medicinal plants: , , and . Fifty (50) participants with clinical and biochemical signs of liver impairment were purposively recruited and treated for a period of 28 days. Participants received at a dose of 30 mL 8 hourly after meals for the treatment period. Clinical and biochemical evaluation (liver panel test, renal function test, haematology, and urinalysis) of subjects for the safety and effectiveness of the product was undertaken at days 0 (baseline), 14, and 28. Compared to the baseline values, did not have any untoward effect on renal function, haematological parameters, and urine parameters of subjects. Clinical and liver panel results of the participants also improved compared to the baseline: serum aspartate transaminase (AST) ( < 0.0001), alanine transaminase (ALT) ( < 0.0001), gamma-glutamyltransferase (GGT) (- 0.0013), total bilirubin (-0.0136), direct bilirubin ( < 0.0001), total proteins (-0.0409), and alkaline phosphates (- 0.0284). Level of albumin showed no significant difference within the study period. The outcome of this study indicates has hepatorestorative action with no observable toxicity and can be used with confidence as indicated as a liver tonic.
全球肝病发病率正在上升，许多发展中国家的患者求助于使用草药产品进行治疗。本研究旨在确定使用一种加纳成品多草药产品治疗肝功能异常患者的安全性和有效性结果。该产品由CPMR用三种药用植物制备而成： 、 和 。有目的地招募了50名有肝功能损害临床和生化体征的参与者，并进行了为期28天的治疗。在治疗期间，参与者饭后每8小时服用一次30毫升的 。在第0天（基线）、第14天和第28天对受试者进行临床和生化评估（肝功能检查、肾功能检查、血液学检查和尿液分析），以评估该产品的安全性和有效性。与基线值相比， 对受试者的肾功能、血液学参数和尿液参数没有任何不良影响。与基线相比，参与者的临床和肝功能检查结果也有所改善：血清天冬氨酸转氨酶（AST）（ ＜0.0001）、丙氨酸转氨酶（ALT）（ ＜0.0001）、γ-谷氨酰转移酶（GGT）（-0.0013）、总胆红素（-0.0136）、直接胆红素（ ＜0.0001）、总蛋白（-0.0409）和碱性磷酸酶（-0.0284）。白蛋白水平在研究期间无显著差异。本研究结果表明 具有肝脏修复作用，无明显毒性，可放心用作肝滋补剂。
