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评价一种新型自动 Hba1c 分析仪对 13 种血红蛋白变异体的分离效果。

Evaluation on the separated effect of 13 hemoglobin variants by a new automatic Hba1c analyzer.

机构信息

Medical Laboratory of Shenzhen Luohu People's Hospital, Shenzhen, China.

Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China.

出版信息

J Clin Lab Anal. 2020 Oct;34(10):e23446. doi: 10.1002/jcla.23446. Epub 2020 Jul 12.

DOI:10.1002/jcla.23446
PMID:32656855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7595897/
Abstract

OBJECTIVE

To evaluate the effect of a new type of automatic glycated hemoglobin analyzer on the separation of abnormal hemoglobin.

METHODS

Samples diagnosed as hemoglobin variants by capillary electrophoresis and gene testing were selected, and HbA1c analyzer was used for separation and detection.

RESULTS

A total of 13 hemoglobin variants in 40 samples could be separated from the normal peaks.

CONCLUSIONS

The variant mode of hemoglobin HbA1c can identify a variety of hemoglobin variants, and the type of variants can be preliminarily determined according to the retention time and characteristic peak shape of the variants.

摘要

目的

评估新型自动糖化血红蛋白分析仪在异常血红蛋白分离方面的效果。

方法

选择经毛细管电泳和基因检测诊断为血红蛋白变异体的样本，采用 HbA1c 分析仪进行分离和检测。

结果

在 40 个样本中，共分离出 13 种可从正常峰中分离出的血红蛋白变异体。

结论

HbA1c 血红蛋白变异体模式可以识别多种血红蛋白变异体，根据变异体的保留时间和特征峰形状可初步确定变异体的类型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd7/7595897/5b245832af8b/JCLA-34-e23446-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd7/7595897/8c4ae6f8b9ad/JCLA-34-e23446-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd7/7595897/5b245832af8b/JCLA-34-e23446-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd7/7595897/8c4ae6f8b9ad/JCLA-34-e23446-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd7/7595897/5b245832af8b/JCLA-34-e23446-g002.jpg

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Evaluation of four hemoglobin separation analyzers for hemoglobinopathy diagnosis.用于血红蛋白病诊断的四种血红蛋白分离分析仪的评估
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Hb Himeji or beta 140 (H18) Ala----Asp. A slightly unstable hemoglobin with increased beta N-terminal glycation.血红蛋白姬路或β140（H18）丙氨酸----天冬氨酸。一种轻度不稳定的血红蛋白，其β氨基末端糖化增加。
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