Department Kinesiology, Health Promotion, and Recreation, College of Education, Applied Physiology Laboratory, University of North Texas, Denton, TX, USA.
Department of Biological Sciences, College of Science, University of North Texas, Denton, TX, USA.
J Diet Suppl. 2021;18(5):461-477. doi: 10.1080/19390211.2020.1786206. Epub 2020 Jul 13.
Endurance running training can lead to gradual accumulation of inflammation and soreness ultimately resulting in overuse injuries. Management of soreness and inflammation with pharmaceuticals (i.e. non-prescription pain relievers) during long-term training is not a suitable solution due to known side effects (e.g. gastrointestinal complications, etc.). Dietary polyphenols (i.e. curcumin, pomegranate, etc.) have been purported to reduce inflammation and muscle soreness, without these negative side effects making them ideal for use in an exercise model. The purpose of the present feasibility study was to explore the combined effect of optimized curcumin and pomegranate extract supplementation prior to (PRE) and after (4H and 24H) an organized half-marathon race on blood inflammatory proteins and inflammation-associated RNA. Daily supplementation (1000 mg/d) started 26 days before a half-marathon which doubled on days 27-31. Data were analyzed with R software and Welch t-test, significance set at < 0.05. At both 4H and 24H, supplementation was associated with alterations in protein (IL-10, IL-13, IL-4, ITAC, MIP-1alpha, MIP-3alpha, BDNF, sIL-2Ralpha, and TNF-alpha; < 0.05) and RNA (CCL22, GUSB, IL-6, LINC00305, NKILA, PTGES, THRIL, TRAF6, ARG2, CD1A, CD55, CFI, CSF2, CXC3CL1, CX3CR1, EDNRB, GATA3, LILRB5, THY1, CD3D, MRC1, GPR183, HAMP, MBL2, CASP3, B2M, KLRF2, PDCD1LG2, IL-10, PTGS2, TLR2, IL-6R, IL-8, IL-7R, MASP1, MYD88, TNFRSF1B, TNFRSF1A, and TIRAP; < 0.05 biomarkers compared to control. Pathway classification of these biomarkers indicated supplementation may be associated with a more favorable muscle recovery profile. Our findings support the notion that combined curcumin and pomegranate supplementation may represent a useful addition to a comprehensive exercise training plan.
耐力跑训练会导致炎症和酸痛的逐渐积累，最终导致过度使用损伤。在长期训练中，使用药物（即非处方止痛药）来治疗疼痛和炎症并不是一个合适的解决方案，因为这会带来已知的副作用（例如胃肠道并发症等）。膳食多酚（例如姜黄素、石榴等）被认为可以减轻炎症和肌肉酸痛，而没有这些负面副作用，使其成为运动模型中使用的理想选择。本可行性研究的目的是探讨在组织半程马拉松比赛前（PRE）和比赛后（4H 和 24H）优化姜黄素和石榴提取物补充剂对血液炎症蛋白和炎症相关 RNA 的综合影响。每日补充剂（1000mg/d）在半程马拉松前 26 天开始，第 27-31 天加倍。数据使用 R 软件和 Welch t 检验进行分析，显著性设置为 < 0.05。在 4H 和 24H 时，补充剂与蛋白质（IL-10、IL-13、IL-4、ITAC、MIP-1alpha、MIP-3alpha、BDNF、sIL-2Ralpha 和 TNF-alpha；< 0.05）和 RNA（CCL22、GUSB、IL-6、LINC00305、NKILA、PTGES、THRIL、TRAF6、ARG2、CD1A、CD55、CFI、CSF2、CXC3CL1、CX3CR1、EDNRB、GATA3、LILRB5、THY1、CD3D、MRC1、GPR183、HAMP、MBL2、CASP3、B2M、KLRF2、PDCD1LG2、IL-10、PTGS2、TLR2、IL-6R、IL-8、IL-7R、MASP1、MYD88、TNFRSF1B、TNFRSF1A 和 TIRAP；< 0.05）和 RNA（CCL22、GUSB、IL-6、LINC00305、NKILA、PTGES、THRIL、TRAF6、ARG2、CD1A、CD55、CFI、CSF2、CXC3CL1、CX3CR1、EDNRB、GATA3、LILRB5、THY1、CD3D、MRC1、GPR183、HAMP、MBL2、CASP3、B2M、KLRF2、PDCD1LG2、IL-10、PTGS2、TLR2、IL-6R、IL-8、IL-7R、MASP1、MYD88、TNFRSF1B、TNFRSF1A 和 TIRAP；< 0.05 相比，与对照组相比。这些生物标志物的途径分类表明，补充剂可能与更有利的肌肉恢复特征有关。我们的发现支持这样一种观点，即联合姜黄素和石榴提取物补充剂可能是综合运动训练计划的有用补充。
