Clinical and Sports Nutrition Research Laboratory (LABINCE), School of Nutrition, Federal University of Goiás, St. 227, Block 68, Setor Leste Universitário, Goiânia, GO, 74.605-080, Brazil.
Laboratory of Biopharmacy and Pharmacokinetics, Federal University of Goiás, Goiânia, GO, 74.605-080, Brazil.
Eur J Appl Physiol. 2020 Jul;120(7):1531-1540. doi: 10.1007/s00421-020-04385-7. Epub 2020 May 2.
Strenuous exercise induces inflammation and muscle damage. Turmeric (Curcuma longa L.) is a widely used spice that exhibits potent anti-inflammatory response and appears to decrease indirect markers of muscle damage. A randomized, double-blind, placebo-controlled trial was conducted to evaluate the effects of Curcuma longa L. extract (CLE) on inflammation and muscle damage after a half-marathon race.
Twenty-eight healthy, normal-weight men were randomly assigned to one of two groups: (1) CLE (3 capsules per day, 500 mg each); or (2) placebo (PLA, 3 capsules per day, 500 mg of microcrystalline cellulose). Participants received the intervention for 4 weeks and immediately before and after the half-marathon race. Creatine kinase, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, myoglobin, interleukins 6 and 10 were assessed at baseline, immediately before, after, and at 2, 24, and 48 h after the half-marathon race.
The half-marathon race increased markers of inflammation and muscle damage. A greater increase in interleukin-10 was observed in the CLE group immediately after the competition compared to the PLA group (7.54 ± 1.45 vs 5.25 ± 0.59 pg/mL; p < 0.05; d = 0.55). Myoglobin concentration was lower 2 h after the race in participants from the CLE group compared to the PLA group (62.10 ± 8.26 vs 107.85 ± 18.45 ng/mL; p = 0.01; d = 0.86).
Curcuma longa L. extract supplementation leads to an increase in IL-10 and decreased myoglobin in recreational male runners after a half-marathon race.
U1111-1179-6335, February 13, 2016.
剧烈运动可引发炎症和肌肉损伤。姜黄（Curcuma longa L.）是一种广泛使用的香料，具有很强的抗炎作用，似乎可以降低肌肉损伤的间接标志物。一项随机、双盲、安慰剂对照试验旨在评估姜黄提取物（CLE）对半程马拉松赛后炎症和肌肉损伤的影响。
28 名健康、体重正常的男性被随机分配到两组中的一组：（1）CLE（每天 3 粒胶囊，每粒 500mg）；或（2）安慰剂（PLA，每天 3 粒胶囊，每粒 500mg 微晶纤维素）。参与者接受干预 4 周，在半程马拉松比赛前和比赛后立即服用。在基线、比赛前、比赛后以及比赛后 2、24 和 48 小时，评估肌酸激酶、乳酸脱氢酶、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、肌红蛋白、白细胞介素 6 和 10。
半程马拉松比赛增加了炎症和肌肉损伤的标志物。与 PLA 组相比，CLE 组在比赛后立即观察到白细胞介素-10 增加更大（7.54 ± 1.45 对 5.25 ± 0.59 pg/mL；p < 0.05；d = 0.55）。与 PLA 组相比，CLE 组的肌红蛋白浓度在比赛后 2 小时较低（62.10 ± 8.26 对 107.85 ± 18.45 ng/mL；p = 0.01；d = 0.86）。
姜黄提取物补充剂可导致半程马拉松赛后休闲男性跑步者的白细胞介素-10 增加和肌红蛋白降低。
U1111-1179-6335，2016 年 2 月 13 日。
