Lim Lena, Howells Henrietta, Radua Joaquim, Rubia Katya
Lee Kong Chian School of Medicine, Imperial College London - Nanyang Technological University Singapore, 636921 Singapore; Department of Child & Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF UK.
Laboratory of Motor Control, Department of Medical Biotechnology and Translational Medicine, University of Milan and Humanitas Research Hospital, Milan, Italy.
Neurosci Biobehav Rev. 2020 Sep;116:406-414. doi: 10.1016/j.neubiorev.2020.07.004. Epub 2020 Jul 10.
We conducted the first meta-analysis of whole-brain voxel-based DTI studies in childhood maltreatment to elucidate regions of white matter (WM) microstructure abnormality relative to non-maltreated controls. Fourteen DTI datasets were included, comprising 386 individuals with childhood maltreatment and 612 non-maltreated controls. Anisotropic effect-size signed differential mapping, a voxel-based meta-analytic method, was used to examine regions of altered fractional anisotropy (FA) in maltreated individuals relative to controls. Maltreated individuals had significantly reduced FA in the left anterior thalamic radiation and bilateral fornix, optic radiations, inferior longitudinal fasciculus, and inferior frontal-occipital fasciculus, along with the anterior portions of the corpus callosum. There were no regions with increased FA. Decreased FA in the callosal genu and body remained in subgroup analyses of unmedicated and drug-free participants. Findings suggest that childhood maltreatment is associated with widespread WM microstructural abnormalities particularly evident in the fornix, corpus callosum and optic radiations, where the neural pathways linking fronto-limbic and occipital visual cortices presumably involved in conveying and processing the (aversive) experience may be compromised in this population.
我们开展了第一项针对童年期受虐全脑基于体素的扩散张量成像（DTI）研究的荟萃分析，以阐明与未受虐对照相比，白质（WM）微观结构异常的区域。纳入了14个DTI数据集，包括386名童年期受虐个体和612名未受虐对照。采用基于体素的荟萃分析方法——各向异性效应大小符号差异映射，来检查受虐个体相对于对照中分数各向异性（FA）改变的区域。受虐个体在左侧丘脑前辐射、双侧穹窿、视辐射、下纵束、额枕下束以及胼胝体前部的FA显著降低。没有FA增加的区域。在未用药和未使用毒品参与者的亚组分析中，胼胝体膝部和体部的FA降低仍然存在。研究结果表明，童年期受虐与广泛的WM微观结构异常有关，尤其在穹窿、胼胝体和视辐射中明显，在这一人群中，连接额边缘和枕叶视觉皮层的神经通路可能参与传递和处理（厌恶）体验，可能受到损害。
