Plasma Aided Biomedical Research Group (pabmed), Biomedical Engineering Division, Graduate School of Science and Technology, TOBB University of Economics and Technology, Ankara 06560, Turkey.
Plasma Aided Biomedical Research Group (pabmed), Biomedical Engineering Division, Graduate School of Science and Technology, TOBB University of Economics and Technology, Ankara 06560, Turkey.
Int J Pharm. 2020 Sep 25;587:119586. doi: 10.1016/j.ijpharm.2020.119586. Epub 2020 Jul 11.
Two types of ampicillin carrier platforms were prepared with polycaprolactone (PCL) and the release behavior of a hydrophilic model drug (ampicillin sodium salt) from those matrices was investigated. Spin coating and electrospinning techniques were used to prepare slab and mat platforms, respectively. Ampicillin sodium salt (ASS) at 5% (w:w) concentration was loaded into the slab or mat structures of PCL. The thickness of the slab was measured 3.349 ± 0.345 μm and surface morphology of the slabs showed uniform PCL spherulites. On the other hand, fiber diameter of PCL and ASS loaded PCL (ASSLPCL) was measured 604 ± 176 nm and 549 ± 119 nm, respectively. The dynamic behavior of the controlled release was improved by a very thin film (<100 nm) formation of sulfur hexafluoride (SF) over the surface via plasma polymerization. Plasma coating was facilitated and speed up the drug diffusion, then led to 45.60 ± 6.46% and 63.67 ± 4.33% enhancement of drug from slab and mat, respectively. Transport mechanism from all matrices showed a Fickian diffusion behavior and plasma modification of the surface did not affected the mechanism. The in vitro antibacterial property of ASS loaded matrices against S. aureus and E. coli was studied through the comparison of bacterial inhibition zones and ASS showed antibacterial effect after all processes.
两种氨苄青霉素载体平台用聚己内酯（PCL）制备，研究了亲水性模型药物（氨苄青霉素钠盐）从这些基质中的释放行为。旋转涂层和静电纺丝技术分别用于制备平板和垫平台。将 5%（w/w）浓度的氨苄青霉素钠盐（ASS）载入 PCL 的平板或垫结构中。平板的厚度测量为 3.349±0.345μm，平板表面形态显示均匀的 PCL 球晶。另一方面，PCL 和载有 ASS 的 PCL（ASSLPCL）的纤维直径分别测量为 604±176nm 和 549±119nm。通过等离子体聚合在表面形成非常薄的六氟化硫（SF）薄膜（<100nm），改善了控制释放的动态行为。等离子体涂层促进并加速了药物扩散，从而使平板和垫的药物释放分别提高了 45.60±6.46%和 63.67±4.33%。所有基质的传输机制均表现出菲克扩散行为，而表面的等离子体改性并未影响该机制。通过比较抑菌圈，研究了载有 ASS 的基质对金黄色葡萄球菌和大肠杆菌的体外抗菌性能，ASS 经过所有处理后均表现出抗菌作用。
