Klockars M, Reitamo S, Reitamo J J, Möller C
Gut. 1977 May;18(5):377-81. doi: 10.1136/gut.18.5.377.
Lysozyme (LZM) was identified in ulcerative colitis in granulocytes, monocytes, and macrophages of the intestinal lamina propria. In contrast with findings in normal colon or rectum, in ulcerative colitis LZM was also detected in some mucosal crypt cells and metaplastic Paneth cells. In both ulcerative colitis and Crohn's disease LZM was present in inflammatory cells of crypt abscesses. In Crohn's disease intense LZM staining was seen in epitheloid cell granulomas. The present observations permit one explanation for the raised concentration of serum-LZM in patients with ulcerative colitis and Crohn's disease.
溶菌酶（LZM）在溃疡性结肠炎患者的肠固有层粒细胞、单核细胞和巨噬细胞中被发现。与正常结肠或直肠的发现不同，在溃疡性结肠炎中，一些黏膜隐窝细胞和化生的潘氏细胞中也检测到了LZM。在溃疡性结肠炎和克罗恩病中，隐窝脓肿的炎症细胞中均存在LZM。在克罗恩病中，上皮样细胞肉芽肿中可见强烈的LZM染色。目前的观察结果为溃疡性结肠炎和克罗恩病患者血清LZM浓度升高提供了一种解释。
