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慢性肝病患者肝活检标本中的淋巴细胞群体。

Lymphocyte populations in liver biopsy specimens from patients with chronic liver disease.

作者信息

Sanchez-Tapias J, Thomas H C, Sherlock S

出版信息

Gut. 1977 Jun;18(6):472-5. doi: 10.1136/gut.18.6.472.

DOI:10.1136/gut.18.6.472
PMID:326639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1411515/
Abstract

The characterisation of lymphocytes from liver biopsies indicates that 'activated' T lymphocytes are present in the liver in alcohol induced hepatitis, chronic active hepatitis (HBS+ve and -ve), and in primary biliary cirrhosis but not in inactive cirrhosis, chronic persistent hepatitis, extrahepatic and drug induced cholestasis. A greater percentage of lymphocytes bear Fc-receptors in chronic active hepatitis than in alcohol induced hepatitis or cholestatic liver disease. The concentration of 'activated' T cells in the peripheral blood in all groups studied was within the normal range, suggesting that the 'activated' T cells found in the liver were reacting to either native or foreign antigens within the liver. The data on Fc-receptor bearing cells are consistent with the involvement of antibody assisted K cell mediated cytotoxicity in chronic active hepatitis.

摘要

对肝活检淋巴细胞的特征分析表明，“活化”的T淋巴细胞存在于酒精性肝炎、慢性活动性肝炎（乙肝表面抗原阳性和阴性）以及原发性胆汁性肝硬化患者的肝脏中，但在静止性肝硬化、慢性持续性肝炎、肝外及药物性胆汁淤积患者的肝脏中则不存在。与酒精性肝炎或胆汁淤积性肝病相比，慢性活动性肝炎中携带Fc受体的淋巴细胞比例更高。在所研究的所有组中，外周血中“活化”T细胞的浓度均在正常范围内，这表明在肝脏中发现的“活化”T细胞正在对肝脏内的自身或外来抗原作出反应。关于携带Fc受体细胞的数据与慢性活动性肝炎中抗体辅助的K细胞介导的细胞毒性作用相符。

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本文引用的文献

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T and B lymphocytes in acute and chronic hepatitis.急性和慢性肝炎中的T淋巴细胞和B淋巴细胞
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Identification by peroxidase staining of monocytes in surface immunofluorescence tests.通过过氧化物酶染色在表面免疫荧光试验中鉴定单核细胞。
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5
Reduction in circulating T lymphocytes in alcoholic liver disease.酒精性肝病中循环T淋巴细胞的减少。
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Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.人类T和B淋巴细胞的表面标志物。I. 大量与绵羊红细胞形成非免疫性玫瑰花结的淋巴细胞。
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Proceedings: Lymphocyte mediated cytotoxicity for Chang liver cells in acute and chronic liver disease.研究报告：急性和慢性肝病中淋巴细胞对张氏肝细胞的细胞毒性作用
Gut. 1976 May;17(5):389.
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Immunological studies in patients with chronic active hepatitis. Cytotoxic activity of lymphocytes to autochthonous liver cells grown in tissue culture.慢性活动性肝炎患者的免疫学研究。淋巴细胞对组织培养中生长的自身肝细胞的细胞毒性活性。
Clin Exp Immunol. 1975 Jan;19(1):99-104.
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Clin Exp Immunol. 1976 Nov;26(2):222-7.
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Lymphocyte cytotoxicity to autologous liver cells in chronic active hepatitis.慢性活动性肝炎中淋巴细胞对自体肝细胞的细胞毒性作用。
Proc Natl Acad Sci U S A. 1975 Apr;72(4):1301-3. doi: 10.1073/pnas.72.4.1301.

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