Sanchez-Tapias J, Thomas H C, Sherlock S
Gut. 1977 Jun;18(6):472-5. doi: 10.1136/gut.18.6.472.
The characterisation of lymphocytes from liver biopsies indicates that 'activated' T lymphocytes are present in the liver in alcohol induced hepatitis, chronic active hepatitis (HBS+ve and -ve), and in primary biliary cirrhosis but not in inactive cirrhosis, chronic persistent hepatitis, extrahepatic and drug induced cholestasis. A greater percentage of lymphocytes bear Fc-receptors in chronic active hepatitis than in alcohol induced hepatitis or cholestatic liver disease. The concentration of 'activated' T cells in the peripheral blood in all groups studied was within the normal range, suggesting that the 'activated' T cells found in the liver were reacting to either native or foreign antigens within the liver. The data on Fc-receptor bearing cells are consistent with the involvement of antibody assisted K cell mediated cytotoxicity in chronic active hepatitis.
对肝活检淋巴细胞的特征分析表明，“活化”的T淋巴细胞存在于酒精性肝炎、慢性活动性肝炎（乙肝表面抗原阳性和阴性）以及原发性胆汁性肝硬化患者的肝脏中，但在静止性肝硬化、慢性持续性肝炎、肝外及药物性胆汁淤积患者的肝脏中则不存在。与酒精性肝炎或胆汁淤积性肝病相比，慢性活动性肝炎中携带Fc受体的淋巴细胞比例更高。在所研究的所有组中，外周血中“活化”T细胞的浓度均在正常范围内，这表明在肝脏中发现的“活化”T细胞正在对肝脏内的自身或外来抗原作出反应。关于携带Fc受体细胞的数据与慢性活动性肝炎中抗体辅助的K细胞介导的细胞毒性作用相符。
