慢性肝病中的外周血淋巴细胞群体
Peripheral blood lymphocyte populations in chronic liver disease.
作者信息
Thomas H C, Freni M, Sanchez-Tapias J, de Villiers D, Jain S, Sherlock S
出版信息
Clin Exp Immunol. 1976 Nov;26(2):222-7.
Abstract
Mature T lymphocyte concentrations are reduced, null cell concentrations are increased, and Fc receptor bearing (B and K) lymphocyte concentrations are normal, in the peripheral blood of patients with chronic hepatocellular or cholestatic liver disease. Some null cells can be stimulated by either thymosin or levamisole to form rosettes with sheep erythrocytes. These changes are present in viral, alcohol associated and 'autoimmune' liver disease and are therefore probably secondary phenomena relating to liver damage.
摘要
在慢性肝细胞性或胆汁淤积性肝病患者的外周血中，成熟T淋巴细胞浓度降低，裸细胞浓度增加，而携带Fc受体的（B和K）淋巴细胞浓度正常。一些裸细胞可被胸腺素或左旋咪唑刺激，与绵羊红细胞形成玫瑰花结。这些变化存在于病毒性、酒精相关性和“自身免疫性”肝病中，因此可能是与肝损伤相关的继发现象。
相似文献
1
Peripheral blood lymphocyte populations in chronic liver disease.慢性肝病中的外周血淋巴细胞群体
Clin Exp Immunol. 1976 Nov;26(2):222-7.
2
Cellular and humoral immune reactions in chronic active liver disease. I. Lymphocyte subsets in liver biopsies of patients with untreated idiopathic autoimmune hepatitis, chronic active hepatitis B and primary biliary cirrhosis.慢性活动性肝病中的细胞免疫和体液免疫反应。I. 未经治疗的特发性自身免疫性肝炎、慢性乙型活动性肝炎和原发性胆汁性肝硬化患者肝活检中的淋巴细胞亚群。
Clin Exp Immunol. 1982 Oct;50(1):17-24.
3
Elevation of gamma delta T lymphocytes in peripheral blood and livers of patients with primary sclerosing cholangitis and other autoimmune liver diseases.原发性硬化性胆管炎及其他自身免疫性肝病患者外周血和肝脏中γδ T淋巴细胞升高。
Hepatology. 1996 May;23(5):988-93. doi: 10.1002/hep.510230508.
4
Lymphocyte populations in chronic active liver disease: in vitro effect of levamisole on T-lymphocyte populations.
Allergol Immunopathol (Madr). 1981 Jan-Feb;9(1):37-44.
5
Circulating B and T lymphocytes in chronic active liver disease.
Acta Med Acad Sci Hung. 1978;35(1):47-52.
6
[Leukocyte migration test in liver diseases].[肝脏疾病中的白细胞迁移试验]
Minerva Med. 1974 Apr 15;65(31):1701-16.
7
Reduced numbers of CD8+ T cells and B cell-expression of Leu-8 antigen in peripheral blood of patients with primary biliary cirrhosis.原发性胆汁性肝硬化患者外周血中CD8 + T细胞数量减少及B细胞Leu - 8抗原表达降低。
Hepatogastroenterology. 1994 Jun;41(3):239-43.
8
Thymosin treatment of chronic hepatitis B: a placebo-controlled pilot trial.
Hepatology. 1991 Sep;14(3):409-15.
9
Involvement of the cytotoxic/suppressor T-cell subset in liver tissue injury of patients with acute and chronic liver diseases.细胞毒性/抑制性T细胞亚群在急慢性肝病患者肝组织损伤中的作用。
Gastroenterology. 1983 Sep;85(3):657-62.
10
Hepatocyte damage induced by lymphocytes from patients with chronic liver diseases, as detected by LDH release.通过乳酸脱氢酶释放检测发现，慢性肝病患者的淋巴细胞可诱导肝细胞损伤。
Clin Exp Immunol. 1978 Mar;31(3):436-42.
引用本文的文献
1
T cell subsets in chronic hepatitis B and the effect of prednisolone withdrawal and interferon alpha-2b.慢性乙型肝炎中的T细胞亚群以及泼尼松龙撤药和α-2b干扰素的作用。
Korean J Intern Med. 1999 Jan;14(1):1-8. doi: 10.3904/kjim.1999.14.1.1.
2
Antibody dependent cellular cytotoxicity in chronic active liver diseases.慢性活动性肝病中的抗体依赖性细胞毒性作用
Gastroenterol Jpn. 1981;16(4):372-6. doi: 10.1007/BF02774470.
3
Immunologic effector mechanisms in hepatitis B-negative chronic active hepatitis.乙型肝炎阴性慢性活动性肝炎中的免疫效应机制。
Springer Semin Immunopathol. 1980 Dec;3(3):317-29. doi: 10.1007/BF02054107.
4
Demonstration of non-specific B-cell stimulation in patients with cirrhosis.肝硬化患者非特异性B细胞刺激的证明。
Gut. 1982 Sep;23(9):724-8. doi: 10.1136/gut.23.9.724.
5
In vitro synthesis of IgG by peripheral blood lymphocytes in chronic liver disease.慢性肝病患者外周血淋巴细胞体外合成免疫球蛋白G
Clin Exp Immunol. 1981 Feb;43(2):370-5.
6
Immunological evaluation of asymptomatic carriers of hepatitis B virus.乙型肝炎病毒无症状携带者的免疫学评估。
Clin Exp Immunol. 1981 Apr;44(1):63-7.
7
Lymphocyte suppressor cell activity in acute and chronic liver disease.急慢性肝病中的淋巴细胞抑制细胞活性。
Clin Exp Immunol. 1981 Jun;44(3):459-66.
8
Impaired T cell function and decreased natural killer activity in patients with liver cirrhosis and their significance in the development of hepatocellular carcinoma.肝硬化患者T细胞功能受损及自然杀伤活性降低及其在肝细胞癌发生中的意义
Gastroenterol Jpn. 1980;15(3):226-32. doi: 10.1007/BF02774272.
9
10
Increased thymic hormone responsive suppressor T lymphocyte function in chronic active hepatitis.慢性活动性肝炎中胸腺激素反应性抑制性T淋巴细胞功能增强。
Dig Dis Sci. 1983 Apr;28(4):328-34. doi: 10.1007/BF01324949.
本文引用的文献
1
CHRONIC ACTIVE ("LUPOID") HEPATITIS; A CLINICAL, SEROLOGICAL, AND PATHOLOGICAL STUDY OF 20 PATIENTS.慢性活动性（“狼疮样”）肝炎；20例患者的临床、血清学及病理学研究
Ann Intern Med. 1965 Mar;62:425-62. doi: 10.7326/0003-4819-62-3-425.
2
THE THYMUS IN HEPATIC CIRRHOSIS.肝硬化中的胸腺
J Clin Pathol. 1963 Sep;16(5):445-7. doi: 10.1136/jcp.16.5.445.
3
The distribution of 51Cr-labeled lymphocytes into antigen-stimulated mice. Lymphocyte trapping.51铬标记淋巴细胞在抗原刺激小鼠体内的分布。淋巴细胞滞留。
J Exp Med. 1971 Jul 1;134(1):224-41. doi: 10.1084/jem.134.1.224.
4
Controlled prospective trial of corticosteroid therapy in active chronic hepatitis.皮质类固醇疗法治疗活动性慢性肝炎的对照前瞻性试验
Q J Med. 1971 Apr;40(158):159-85. doi: 10.1093/oxfordjournals.qjmed.a067264.
5
The effect of measles on the thymus and other lymphoid tissues.麻疹对胸腺及其他淋巴组织的影响。
Clin Exp Immunol. 1973 Mar;13(3):343-57.
6
T and B lymphocytes in acute and chronic hepatitis.急性和慢性肝炎中的T淋巴细胞和B淋巴细胞
Clin Immunol Immunopathol. 1974 Apr;2(3):353-60. doi: 10.1016/0090-1229(74)90053-1.
7
Antibody in the induction and inhibition of lymphocyte cytotoxicity.抗体在淋巴细胞细胞毒性的诱导和抑制中的作用。
Transplant Rev. 1972;13:67-90. doi: 10.1111/j.1600-065x.1972.tb00060.x.
8
Human T lymphocyte "E" rosette function. I. A process modulated by intracellular cyclic AMP.人T淋巴细胞“E”花环功能。I. 一个受细胞内环磷酸腺苷调节的过程。
J Exp Med. 1974 Oct 1;140(4):1122-6. doi: 10.1084/jem.140.4.1122.
9
Reduction in circulating T lymphocytes in alcoholic liver disease.酒精性肝病中循环T淋巴细胞的减少。
Lancet. 1974 Aug 31;2(7879):488-90. doi: 10.1016/s0140-6736(74)92015-7.
10
Role of the liver in controlling the immunogenicity of commensal bacteria in the gut.肝脏在控制肠道共生细菌免疫原性中的作用。
Lancet. 1973 Jun 9;1(7815):1288-91. doi: 10.1016/s0140-6736(73)91300-7.
Zotero 插件