特应性皮炎的润肤治疗：最新证据与临床考量
Emollient treatment of atopic dermatitis: latest evidence and clinical considerations.
作者信息
Hon Kam Lun, Kung Jeng Sum Charmaine, Ng Wing Gi Gigi, Leung Ting Fan
机构信息
Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong.
出版信息
Drugs Context. 2018 Apr 17;7:212530. doi: 10.7573/dic.212530. eCollection 2018.
AIM
To review current classes of emollients in the market, their clinical efficacy in atopic dermatitis (AD) and considerations for choice of an emollient.
METHODS
PubMed Clinical Queries under Clinical Study Categories (with Category limited to Therapy and Scope limited to Narrow) and Systematic Reviews were used as the search engine. Keywords of 'emollient or moisturizer' and 'atopic dermatitis' were used.
OVERVIEW OF FINDINGS
Using the keywords of 'emollient' and 'atopic dermatitis', there were 105 and 36 hits under Clinical Study Categories (with Category limited to Therapy and Scope limited to Narrow) and Systematic Reviews, respectively. Plant-derived products, animal products and special ingredients were discussed. Selected proprietary products were tabulated.
CONCLUSIONS
A number of proprietary emollients have undergone trials with clinical data available on PubMed-indexed journals. Most moisturizers showed some beneficial effects, but there was generally no evidence that one moisturizer is superior to another. Choosing an appropriate emollient for AD patients would improve acceptability and adherence for emollient treatment. Physician's recommendation is the primary consideration for patients when selecting a moisturizer/emollient; therefore, doctors should provide evidence-based information about these emollients.
目的
综述市场上现有的润肤剂类别、它们在特应性皮炎（AD）中的临床疗效以及选择润肤剂时的注意事项。
方法
以临床研究类别下的PubMed临床查询（类别限于治疗，范围限于狭义）和系统评价作为搜索引擎。使用“润肤剂或保湿剂”和“特应性皮炎”作为关键词。
研究结果概述
使用“润肤剂”和“特应性皮炎”作为关键词，在临床研究类别（类别限于治疗，范围限于狭义）和系统评价下分别有105条和36条命中结果。讨论了植物源产品、动物产品和特殊成分。列出了选定的专利产品。
结论
许多专利润肤剂已经在PubMed索引期刊上发表了带有临床数据的试验。大多数保湿剂都显示出一些有益效果，但一般没有证据表明一种保湿剂优于另一种。为AD患者选择合适的润肤剂将提高润肤剂治疗的可接受性和依从性。医生的建议是患者选择保湿剂/润肤剂时的首要考虑因素；因此，医生应提供有关这些润肤剂的循证信息。
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