生物相关配体及其镁配合物的配位化学。

Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY 13244, USA.

Molecules. 2020 Jul 11;25(14):3172. doi: 10.3390/molecules25143172.

The coordination chemistry of magnesium (Mg) was extensively explored. More recently; magnesium; which plays a role in over 80% of metabolic functions and governs over 350 enzymatic processes; is becoming increasingly linked to chronic disease-predominantly due to magnesium deficiency (hypomagnesemia). Supplemental dietary magnesium utilizing biorelevant chelate ligands is a proven method for counteracting hypomagnesemia. However, the coordination chemistry of such bio-relevant magnesium complexes is yet to be extensively explored or elucidated. It is the aim of this review to comprehensively describe what is currently known about common bio-relevant magnesium complexes from the perspective of coordination chemistry.

镁的配位化学得到了广泛的探索。最近，镁在超过 80%的代谢功能中发挥作用，控制着超过 350 种酶促过程，由于镁缺乏（低镁血症），镁与慢性疾病的联系越来越紧密。利用生物相关的螯合配体补充膳食镁是对抗低镁血症的一种已被证实的方法。然而，这种生物相关的镁配合物的配位化学尚未得到广泛的探索或阐明。本文综述的目的是从配位化学的角度全面描述目前已知的常见生物相关镁配合物。