Liu Jing, Cui Min, Yang Tao, Yao Ping
Gastroenterology, Xinjiang Medical University Affiliated First Hospital, Urumqi, Xinjiang, China.
Gastroenterology, Xinjiang Medical University Affiliated First Hospital, Urumqi, Xinjiang, China
BMJ Open Gastroenterol. 2020 Jul;7(1). doi: 10.1136/bmjgast-2020-000437.
To study the correlation between gastrointestinal (GI) symptoms and disease severity in patients with COVID-19.
We searched six databases including three Chinese and three English databases for all the published articles on COVID-19. Studies were screened according to inclusion and exclusion criteria. The relevant data were extracted and all the statistical analyses were performed using Revman5.3.
In a meta-analysis of 9 studies, comprising 3022 patients, 479 patients (13.7%, 95% CI 0.125 to 0.149) had severe disease and 624 patients (14.7%, 95% CI 0.136 to 0.159) had GI symptoms. Of 624 patients with GI symptoms, 118 patients had severe disease (20.5%, 95% CI 0.133 to 0.276) and of 2397 cases without GI symptoms, 361 patients had severe disease (18.2%, 95% CI 0.129 to 0.235). Comparing disease severity of patients with and without GI symptoms, the results indicated: I²=62%, OR=1.21, 95% CI 0.94 to 1.56, p=0.13; there was no statistically significant difference between the two groups. The funnel plot was symmetrical with no publication bias.
Current results are not sufficient to demonstrate a significant correlation between GI symptoms and disease severity in patients with COVID-19.
研究新型冠状病毒肺炎（COVID-19）患者胃肠道（GI）症状与疾病严重程度之间的相关性。
我们检索了六个数据库，包括三个中文数据库和三个英文数据库，以查找所有已发表的关于COVID-19的文章。根据纳入和排除标准对研究进行筛选。提取相关数据，并使用Revman5.3进行所有统计分析。
在一项对9项研究的荟萃分析中，共纳入3022例患者，其中479例（13.7%，95%CI 0.125至0.149）患有重症疾病，624例（14.7%，95%CI 0.136至0.159）有胃肠道症状。在624例有胃肠道症状的患者中，118例患有重症疾病（20.5%，95%CI 0.133至0.276）；在2397例无胃肠道症状的患者中，361例患有重症疾病（18.2%，95%CI 0.129至0.235）。比较有和无胃肠道症状患者的疾病严重程度，结果显示：I² = 62%，OR = 1.21，95%CI 0.94至1.56，p = 0.13；两组之间无统计学显著差异。漏斗图对称，无发表偏倚。
目前的结果不足以证明COVID-19患者的胃肠道症状与疾病严重程度之间存在显著相关性。
