Rubert Andrea, Bagán Leticia, Bagán Jose V
Assistant Professor of Oral Medicine. European University of Valencia.
Associate Professor of Oral Medicine. University of Valencia. Av. de Blasco Ibáñez, 15, 46010 València.
J Clin Exp Dent. 2020 Jun 1;12(6):e540-e546. doi: 10.4317/jced.57091. eCollection 2020 Jun.
A retrospective clinical-histopathological study was made of the evolution of oral leukoplakia over time, staging the disease according to the classification of van der Waal.
A study was made of 412 patients with oral leukoplakia, analyzing the corresponding clinical factors and histopathological findings; assessing associations between the different clinical presentations and epithelial dysplasia; and evaluating the factors influencing malignant transformation of the lesions.
Clinically, homogeneous presentations were seen to predominate (n = 336, 81.6%), while histologically most of the lesions exhibited no dysplastic changes (n = 271; 65.7%). Stage 1 of the van der Waal classification was the most common presentation (n = 214; 51.9%). The lesion malignization rate was 8.3%, and the factors associated to a significantly increased malignization risk were non-homogeneous OL lesions (=0.00), lesion location in the tongue (=0.00), and the presence of epithelial dysplasia (=0.00).
In our series of patients with oral leukoplakia, malignization was associated to the less common clinical presentations of the disease, i.e., non-homogeneous lesions, and the latter tended to exhibit high grade epithelial dysplasia. Oral leukoplakia, potentially malignant disorders, malignant transformation.
对口腔白斑随时间的演变进行了一项回顾性临床组织病理学研究，根据范德瓦尔分类法对该疾病进行分期。
对412例口腔白斑患者进行研究，分析相应的临床因素和组织病理学发现；评估不同临床表现与上皮发育异常之间的关联；并评估影响病变恶变的因素。
临床上，均质型表现占主导（n = 336，81.6%），而组织学上大多数病变无发育异常改变（n = 271；65.7%）。范德瓦尔分类的1期是最常见的表现（n = 214；51.9%）。病变恶变率为8.3%，与恶变风险显著增加相关的因素是非均质型口腔白斑病变（P=0.00）、病变位于舌部（P=0.00）以及存在上皮发育异常（P=0.00）。
在我们的口腔白斑患者系列中，恶变与该疾病较不常见的临床表现相关，即非均质型病变，且后者往往表现为高级别上皮发育异常。口腔白斑、潜在恶性疾病、恶变
