Elliott P, Forrest R D, Jackson C A, Yudkin J S
Department of Epidemiology, London School of Hygeine and Tropical Medicine, UK.
J Hum Hypertens. 1988 Aug;2(2):89-95.
Blood pressure (BP) and 24-hr urinary sodium (Na) and potassium (K) excretion were measured in 58 men and women aged 40 and above who were selected randomly from the age-sex register of a general practice in North London. All 58 urine collections were reported as complete, but only 28/56 (50%) were classified as 'complete' by the excretion of a biological marker, p-aminobenzoic acid (PABA). Reliability of Na excretion estimated from repeated urine collections was 0.86, indicating that variability of Na excretion within individuals in this middle-aged and elderly population was low. Systolic blood pressure (SBP) was significantly related to 24-hr Na excretion and to 24-hr Na/creatinine ratio. After adjustment for age, sex and body mass index, a SBP-Na regression coefficient of 0.091 mmHg/mmol Na (P = 0.02) was observed. On simple regression analysis, a significant association was also found between diastolic blood pressure and Na (P = 0.04). In the sub-group classified as 'complete' collectors by PABA excretion, BP-Na regression coefficients were larger than in analyses of the sample as a whole. BP was not significantly related to K or Na/K.
对从伦敦北部一家普通诊所的年龄-性别登记册中随机选取的58名40岁及以上的男性和女性测量了血压（BP）、24小时尿钠（Na）和钾（K）排泄量。所有58份尿液收集报告均为完整，但根据生物标志物对氨基苯甲酸（PABA）的排泄情况，只有28/56（50%）被归类为“完整”。从重复尿液收集估计的钠排泄可靠性为0.86，表明该中老年人群个体内钠排泄的变异性较低。收缩压（SBP）与24小时钠排泄量以及24小时钠/肌酐比值显著相关。在对年龄、性别和体重指数进行调整后，观察到SBP-钠回归系数为0.091 mmHg/mmol钠（P = 0.02）。在简单回归分析中，舒张压与钠之间也发现了显著关联（P = 0.04）。在按PABA排泄归类为“完整”收集者的亚组中，血压-钠回归系数大于对整个样本的分析。血压与钾或钠/钾无显著关联。
