Isaksson Marléne, Ryberg Kristina, Goossens An, Bruze Magnus
Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, SE-205 02, Malmö, Sweden.
Department of Dermatology, Uddevalla Hospital, S-451 80, Uddevalla, Sweden.
Contact Dermatitis. 2015 Jul;73(1):15-20. doi: 10.1111/cod.12400. Epub 2015 Apr 27.
Disperse dyes are common sensitizers, but are not currently included in the European baseline series.
To justify the inclusion of a textile dye mix in the European baseline patch test series.
A survey of the reported frequencies of contact allergy to textile dyes and textile dye mixes was performed by searching PubMed (http://www.ncbi.nlm.gov.ludwig.lub.lu.se/pubmed, last accessed 14 December 2014). The results from a multicentre study performed within the European Environmental Contact Dermatitis Research Group (EECDRG) and published in 2014 formed the final basis for the recommendation.
The EECDRG study performed in Europe and the United States showed that 2.1-6.9% of consecutively tested dermatitis patients reacted to a 6.6% wt/wt textile dye mix consisting of eight disperse dyes. The clinical relevance was ascertained in >30% of the positive cases. A high frequency of simultaneous sensitivity to Disperse Orange 3 (DO 3) and p-phenylenediamine (PPD) was seen. Active sensitization to the mix was not noted.
It is recommended to include a 6.6% textile dye mix consisting of eight disperse dyes in the European baseline series, even though one component, DO 3, may be superfluous, owing to its frequent cross-reactivity with PPD. Removal of DO 3 from the mix would need further study.
分散染料是常见的致敏剂，但目前未被纳入欧洲基线系列。
证明将一种纺织染料混合物纳入欧洲基线斑贴试验系列的合理性。
在欧洲和美国进行的EECDRG研究表明，连续检测的皮炎患者中有2.1%-6.9%对由8种分散染料组成的6.6%（重量/重量）纺织染料混合物有反应。在超过30%的阳性病例中确定了临床相关性。观察到对分散橙3（DO 3）和对苯二胺（PPD）同时敏感的频率较高。未发现对该混合物有主动致敏现象。
建议在欧洲基线系列中纳入由8种分散染料组成的6.6%纺织染料混合物，尽管其中一种成分DO 3可能多余，因为它与PPD频繁交叉反应。从混合物中去除DO 3需要进一步研究。
