From the *Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden; †Allergy Center and Department of Dermatology, University Hospital, Republic University of Uruguay, Montevideo, Uruguay; ‡Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, Odense, Denmark; §Department of Social Medicine, Occupational and Environmental Dermatology, University Heidelberg, Heidelberg, Germany; ∥Department of Dermatology, National Skin Center, Singapore, Singapore; ¶Allergy Unit, Department of Dermatology, University Hospital K.U.Leuven, Leuven, Belgium; #MGM Medical College, Kamothe, Mumbai, India; **Department of Dermatology UCSF, School of Medicine, San Francisco, CA; and ††Division of Dermatology, Mc Gill University Health Centre, Royal Victoria Hospital, Montréal, QC, Canada.
Dermatitis. 2015 Jul-Aug;26(4):170-6. doi: 10.1097/DER.0000000000000125.
Disperse dyes are well-known contact sensitizers not included in the majority of commercially available baseline series.
To investigate the outcome of patch testing to a textile dye mix (TDM) consisting of 8 disperse dyes.
Two thousand four hundred ninety-three consecutive dermatitis patients in 9 dermatology clinics were patch tested with a TDM 6.6%, consisting of Disperse (D) Blue 35, D Yellow 3, D Orange 1 and 3, D Red 1 and 17, all 1.0% each, and D Blue 106 and D Blue 124, each 0.3%. 90 reacted positively to the TDM. About 92.2% of the patients allergic to the TDM were also tested with the 8 separate dyes.
Contact allergy to TDM was found in 3.6% (1.3-18.2) Simultaneous reactivity to p-phenylenediamine was found in 61.1% of the TDM-positive patients. Contact allergy to TDM and not to other p-amino-substituted sensitizers was diagnosed in 1.2%. The most frequent dye allergen in the TDM-positive patients was D Orange 3.
Over 30% of the TDM allergic patients had been missed if only the international baseline series was tested. Contact allergy to TDM could explain or contribute to dermatitis in over 20% of the patients. Textile dye mix should be considered for inclusion into the international baseline series.
分散染料是众所周知的接触致敏原，不包含在大多数市售基础系列中。
调查由 8 种分散染料组成的纺织品染料混合物（TDM）进行斑贴试验的结果。
在 9 个皮肤科诊所，对 2493 例连续的皮炎患者进行 TDM（6.6%）斑贴试验，其成分为分散（D）蓝 35、D 黄 3、D 橙 1 和 3、D 红 1 和 17，各 1.0%，D 蓝 106 和 D 蓝 124，各 0.3%。90 例对 TDM 呈阳性反应。对 TDM 过敏的患者中，约 92.2%也用 8 种单独的染料进行了测试。
在 3.6%（1.3-18.2）的患者中发现对 TDM 的接触过敏。在 TDM 阳性患者中，有 61.1%同时对 p-苯二胺有反应。在诊断为 TDM 过敏而非其他 p-氨基取代敏化剂过敏的患者中占 1.2%。在 TDM 阳性患者中最常见的染料过敏原是 D 橙 3。
如果仅检测国际基础系列，超过 30%的 TDM 过敏患者将被遗漏。对 TDM 的接触过敏可能会解释或导致超过 20%的患者出现皮炎。纺织品染料混合物应考虑纳入国际基础系列。
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