Department of Environmental Sciences and Engineering, College of Architecture and Environment, Sichuan University, Chengdu, 610065, China.
Human Sperm Bank, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of the Ministry of Education for Maternal and Child Diseases and Birth Defects, Chengdu, 610041, China.
Environ Res. 2020 Jul;186:109528. doi: 10.1016/j.envres.2020.109528. Epub 2020 Apr 15.
Ambient air pollution has adverse effects on human health and reproduction. A number of studies have suggested a significant association between ambient air pollution and human fecundity, with most studies focusing on cross-sectional data from the general male population with single semen samples. We conducted a retrospective study in China using longitudinal analysis of repeated semen samples to investigate the association between environmental exposure parameters (e.g., PM, PM, SO, NO, CO, ground temperature, and relative humidity) and sperm quality parameters (e.g., semen volume, sperm concentration, forward motility concentration, and percentage of progressive rate) during different exposure windows (current day, 90-day preceding). Data from 686 males and 4841 semen samples collected between 2013 and 2018 at Sichuan Provincial Sperm Bank were included in a mixed-effects model analysis. The study population was young, healthy, and well-educated. The results indicate that 90-day average concentrations of PM, PM and CO were negatively associated with sperm concentration and forward motility concentration, whereas 90-day average concentration of O was positively associated with forward motility concentration. Between-subject variability played the dominant role in overall model variance. Our results suggest that chronic exposure to particulate matter and CO may interfere with spermatogenesis.
大气污染对人类健康和生殖能力有不良影响。许多研究表明，大气污染与人类生殖能力之间存在显著关联，大多数研究集中在一般男性人群的横断面数据和单次精液样本上。我们在中国进行了一项回顾性研究，采用纵向分析重复精液样本，以调查环境暴露参数（如 PM、PM、SO、NO、CO、地面温度和相对湿度）与精子质量参数（如精液量、精子浓度、前向运动浓度和渐进率百分比）在不同暴露窗口（当前日、前 90 日）之间的关联。纳入了 2013 年至 2018 年期间在四川省精子库收集的 686 名男性和 4841 份精液样本的混合效应模型分析。研究人群年轻、健康且受教育程度高。结果表明，PM、PM 和 CO 的 90 天平均浓度与精子浓度和前向运动浓度呈负相关，而 O 的 90 天平均浓度与前向运动浓度呈正相关。个体间变异性在总模型方差中起主导作用。我们的结果表明，慢性暴露于颗粒物和 CO 可能会干扰精子发生。
